antimetabolite


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Related to antimetabolite: methotrexate

antimetabolite

 [an″te-, an″ti-mĕ-tab´o-līt]
1. a substance bearing a close structural resemblance to one required for normal physiological functioning, and exerting its effect by interfering with the utilization of the essential metabolite.
2. a class of antineoplastic agents consisting of antimetabolites of substances required for cell growth and replication; the interference with cell function is phase specific, largely in the S phase of the cell cycle. The group includes cladribine, cytarabine, floxuridine, fludarabine, fluorouracil, mercaptopurine, methotrexate, and thioguanine. See also antineoplastic therapy.

an·ti·me·tab·o·lite

(an'tē-me-tab'ō-līt),
A substance that competes with, replaces, or antagonizes a particular metabolite; for example, ethionine is an antimetabolite of methionine.

antimetabolite

/an·ti·me·tab·o·lite/ (an″te-) (an″ti-mĕ-tab´o-līt) a substance bearing a close structural resemblance to one required for normal physiological functioning, and exerting its effect by interfering with the utilization of the essential metabolite.

antimetabolite

(ăn′tē-mĭ-tăb′ə-līt′, ăn′tī-)
n.
A substance that closely resembles an essential metabolite and therefore inhibits physiological reactions involving that metabolite.

an′ti·met′a·bol′ic (-mĕt′ə-bŏl′ĭk) adj.

antimetabolite

[-mətab′əlīt]
Etymology: Gk, anti + metabole, change
a drug or other substance that is an antagonist to or resembles a normal human metabolite and interferes with its function in the body, usually by competing for its receptors or enzymes. Among the antimetabolites used as antineoplastic agents are the folic acid analog methotrexate and the pyrimidine analog fluorouracil. The antineoplastic mercaptopurine, an analog of the nucleotide adenine and the purine base hypoxanthine, is a metabolic antagonist of both compounds. Thioguanine, another member of a large series of purine analogs, interferes with nucleic acid synthesis. Cytarabine, used in the treatment of acute myelocytic leukemia, is a synthetic nucleoside that resembles cytidine and kills cells that actively synthesize deoxyribonucleic acid (DNA), apparently by inhibiting the enzyme DNA polymerase.

antimetabolite

Antimetabolic agent Pharmacology Any agent–eg, MTX, 6-mercaptopurine, thioguanine, 5-FU, gemcitabine that is a structural analogue of a native cell metabolite, which either inhibits the enzymes of a particular metabolic pathway or is incorporated during synthesis to produce defective product or prevents replication; anti-metabolites are used as chemotherapeutics, antivirals and as immunosuppressants, and include analogues of purines–eg azathioprine, pyrimidines, folic acid–eg aminopterin, MTX See Azathioprine, Methotrexate.

an·ti·me·tab·o·lite

(an'tē-mĕ-tab'ō-līt)
A substance that competes with, replaces, or antagonizes a particular metabolite; e.g., ethionine is an antimetabolite of methionine.

antimetabolite

An anticancer, or CYTOTOXIC, drug which acts by combining with essential enzymes within cancer cells so as to interfere with their metabolism and growth. To be useful, antimetabolites must be significantly more toxic to cancer cells than to normal cells.

Antimetabolite

A drug that interferes with a cell's growth or ability to multiply.
Mentioned in: Chemotherapy

antimetabolite

a substance bearing a close structural resemblance to one required for normal physiological functioning, and exerting its effect by interfering with the utilization of the essential metabolite.
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Drugs have been analyzed by segments such as angiogenesis inhibitor, EGFR inhibitor, kinase inhibitor, microtubule stabilizer, folate antimetabolites, and PD-1/PD-L1 inhibitor.
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One of a group of chemotherapy drugs known as antimetabolites, it prevents cells from making DNA and RNA - ribonucleic acid - which causes cells to die.
Other topics of the 66 chapters include topoisomerase inhibitors, antimetabolites, cytokines, monoclonal antibodies, biophosphonates, anemia, metabolic emergencies, and pain management.
Antimetabolites are substances that are chemically very similar to the building blocks of DNA and RNA--purine and pyrimidine.
Antimetabolites are a broad class of drugs that interferes with the basic metabolism of cancer cells.
5) Current therapy involves the use of combinations of steroids (topical, oral, and IV), antimetabolites, and cytotoxic medications.
The growth spurt will be fueled by the development of new drugs with fewer side effects and prophylactic uses of acute immunosuppressive therapies such as novel antimetabolites, monoclonal, and polyclonal antibodies, which will increase the success of transplants, the company reports.
He starts with Paul Ehrlich's antitreponemal arsenicals and ends with the antisense agents now in early clinical trials for the treatment of autoimmune diseases and cancer, covering in the process the development of antibacterial and antiviral agents, vaccines, antimetabolites, and hormone-based antineoplastic agents.