antiinhibitor coagulant complex
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antiinhibitor coagulant complex (AICC)
a concentrated fraction from pooled human plasma, which includes vitamin K-dependent coagulation factors (factors II,VII, IX, and X), factors of the kinin-generating system, and factor VIII coagulant antigen. It is administered intravenously as an antihemorrhagic in hemophilic patients with factor VIII inhibitors. Its mechanism of action has not been elucidated but may result at least from part to its factor Xa content.