Various attempts have been undertaken to investigate the positive effects of pharmacological antihypotensive therapy on mental functioning (Duschek et al.
Studies investigating the effects of antihypotensive drugs on extended time base are rare.
The patient should be observed for the possible development of arrhythmias and hypotension; if required, appropriate antiarrhythmic and antihypotensive
therapy should be given.
If postural hypotension persists despite these measures, a physician may order an antihypotensive
agent such as fludrocortisone or midodrine (Mathias & Kimber, 1999).
There is also a need for symptomatic treatment, in addition to the prophylactic use, of an antihypotensive
agent to increase systolic blood pressure in a patient while undergoing dialysis.
The positive association between the increase in blood pressure and cognitive enhancement suggests that blood pressure plays a casual role in the cognitive deficits in hypotension and underlines that they can be reduced through antihypotensive treatment.
First attempts have been undertaken to investigate the effects of pharmacological antihypotensive therapy on mental functioning (Duschek et al.
2007a,b) have so far been able to show a beneficial effect of an antihypotensive agent on cognitive function.
Among available antihypotensive
drugs, only few orally administered preparations suitable for treatment have the desired effect (Oldenburg et al.
Among the available antihypotensive drugs, only few orally applied preparations suitable for long-term treatment have the desired effect (Oldenburg et al.
Exclusion criteria were therapy with antihypotensive agents or migraine medications; myocardial infarction; stroke; renal or hepatic diseases; allergy to the ingredients; overweight; underweight; and participation in another drug study.