antihuman globulin


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an·ti·hu·man glob·u·lin

serum from a rabbit or other animal previously immunized with purified human globulin to prepare antibodies directed against human immunoglobulin, some of which may be used in the direct and indirect Coombs tests.
Synonym(s): Coombs serum

an·ti·hu·man glob·u·lin

(an'tē-hyū'măn glob'yū-lin)
Serum from a rabbit or other animal previously immunized with purified human globulin to prepare antibodies directed against IgG and complement; used in the direct and indirect Coombs tests.
Synonym(s): Coombs serum.

Coombs,

Robin R.A., English veterinarian and immunologist, 1921–.
Coombs serum - serum from a rabbit or other animal previously immunized with purified human globulin to prepare antibodies directed against IgG and complement. Synonym(s): antihuman globulin
Coombs test - a test for antibodies, the so-called antihuman globulin test, using either the direct or indirect Coombs tests. Synonym(s): antiglobulin test
direct Coombs test - a test for detecting sensitized erythrocytes in erythroblastosis fetalis and in cases of acquired immune hemolytic anemia.
Gell and Coombs reaction - see under Gell
indirect Coombs test - a test routinely performed in cross-matching blood or in the investigation of transfusion reaction.
References in periodicals archive ?
All samples were processed for donor recipient crossmatch using routine incubation CDC, extended incubation CDC and antihuman globulin CDC.
Comparison of extended incubation CDC to the antihuman globulin CDC showed no significant difference (two tailed p=0.
They also noted that all patients who were transplanted across a positive anti-human globulin CDC but negative extended incubation CDC developed accelerated or acute rejection within two months post-transplant, whereas those who were transplanted across a positive extended incubation crossmatch but negative antihuman globulin CDC had neither hyper-acute or accelerated rejection (7).
Gel cards with antihuman globulin reagent were used for indirect antiglobulin tests.
43] ACOG has opined that critical titre of anti-D in maternal sera was usually 16 or 32 in the antihuman globulin phase.
Sensitivity and Specificity of the 6540 Mean Fluorescent Intensity (MFI) Cutoff Value for Class I Donor-Specific Antibody (DSA) Strength in Predicting Positive Complement-Dependent Cytotoxicity Antihuman Globulin T-Cell Crossmatches (CDC-AHG T-Cell XMs) in Proficiency Test and Patient Samples Positive Negative CDC-AHG CDC-AHG Samples, MFI No.