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antiglobulin

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antiglobulin /an·ti·glob·u·lin/ (an″te-) (an″ti-glob″u-lin) an antibody directed against gamma globulin, as used in the antiglobulin test.
antiglobulin
[an′tiglob′yoo͡lin]
Etymology: Gk, anti + L, globulus, small globe
an antibody that occurs naturally or is prepared in laboratory animals to be used against human globulin. Specific antiglobulins are used in the detection of specific antibodies, as in blood typing. See also antiglobulin test, precipitin.

antiglobulin [an″tĭ-glob´u-lin]
an antibody directed against gamma globulin.
antiglobulin test (AGT) Coombs' test.

antiglobulin
an antibody to a heterologous antibody, such as goat antihorse IgG antibody, as used in the Coombs test, ELISA, immunofluorescence or other assays.

antiglobulin test


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Current guidelines for HS diagnosis include family history, splenomegaly, abnormal CBC indices [spherocytes identification; increase in MCHC (mean corpuscular hemoglobin concentration)], reticulocytes, and RDW (red cell distribution width); and decrease in Hb (hemoglobin) and MCV (mean cell volume), a negative direct antiglobulin test, increased bilirubin, and reticulocytosis.
Results of the patient's direct antiglobulin test (DAT) were strongly positive using broad-spectrum reagents and anti-immunoglobulin G (IgG) and C3 antibodies.
Additional assays, such as weak D, antibody identification, Rh and Kell phenotyping, crossmatching and direct antiglobulin testing - which recently received FDA clearance for use on the TANGO - will increase the utility of the instrument.
 
 
 
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