Mechanisms and molecular pathways underlying antigenic variation
of Borreliahermsii variable major lipoprotein (Vmp) and B.
These multigene families are responsible for the antigenic variation
of the parasite in natural infections which enables it to escape the host immune response for its survival resulting in prolonged chronic infections.
The virus undergoes antigenic variation
year by year due to the selection of antigenic variants by immunological pressure of the hosts.
The process by which an influenza virus mutates to evade immune systems is called antigenic variation
TABLE 1 Hemagglutination-inhibition titers of influenza B viruses [*] -- United States and worldwide, May-September 25, 2001 Antisera B/Sichuan/ B/Victoria/ B/Hong Kong/ Viral antigen 379/99 504/2000 6/2001 B/Yamagata/16/88 group viruses B/Sichuan/379/99 320 2560 20 B/Victoria/504/2000 320 2560 10 B/Victoria/2/87 group viruses B/Hong Kong/6/2001 [less than]10 20 1280 B/Hong Kong/22/2001 [less than]10 10 640 B/Hong Kong/ Viral antigen 22/2001 B/Yamagata/16/88 group viruses B/Sichuan/379/99 10 B/Victoria/504/2000 [less than]10 B/Victoria/2/87 group viruses B/Hong Kong/6/2001 640 B/Hong Kong/22/2001 640 (*)A fourfold difference in hemagglutination-inhibition titer betwen two viruses usually indicates antigenic variation
2012), who reported that ND outbreaks are not due to antigenic variation
In antigenic variation
mechanism when a parasite e.
Finally, wepropose to exploit the extraordinary potential of trypanosomes for antigenic variation
in order to produceSRA variants able to neutralize the pathogenic APOL1 variants.
Four hypervariable domains in this region, variable domains (VD) I-IV, are responsible for the large degree of antigenic variation
in this gene.
The text blends classical and medical parasitology with more modern disciplines, discussing the molecular and immunological basis for pathogenesis, metabolic pathways, and antigenic variation
for the protozoan pathogens.