antigenic determinant


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Related to antigenic determinant: hapten, Clonal selection

determinant

 [de-ter´mĭ-nant]
a factor that establishes the nature of an entity or event.
antigenic determinant a site on the surface of an antigen molecule to which a single antibody molecule binds; generally an antigen has several or many different antigenic determinants and reacts with many different antibodies. Called also epitope.
 Antigens contain antigenic determinants (epitopes) and antibodies contain antibody combining sites (paratopes). From Copstead and Banasik, 2000.
hidden determinant an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
immunogenic determinant the part of an immunogenic molecule that interacts with a helper T cell in triggering antibody production as opposed to the antigenic determinant or hapten, which interacts with B cells.

an·ti·gen·ic de·ter·mi·nant

the particular chemical group of a molecule that determines immunologic specificity.
Synonym(s): determinant group

antigenic determinant

a site on an antigen molecule to which an antibody molecule binds. Also called epitope.

an·ti·gen·ic de·ter·mi·nant

(an'ti-jen'ik dĕ-tĕr'mi-nănt)
The particular chemical group of a molecule that determines immunologic specificity.

antigenic determinant

A cluster of EPITOPES.

antigenic determinant

see EPITOPE.

determinant

a factor that establishes or changes the nature of an entity or event. The factor may be environmental, be a part of the host or its defenses, be single or multiple and be immediate or remote.

allotypic determinant
an antigenic determinant which varies among members of the same species.
antigenic determinant
a structural component of an antigen against which immune responses are made and to which antibody or T cell receptor binds; an antigen such as a protein has many antigenic determinants. Called also epitope.
disease d's
factors which affect the occurrence or rate of ocurrence of a disease.
hidden determinant
an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
isotypic determinant
one that occurs in all individuals of the same species.
References in periodicals archive ?
These CAP-RASTs are 80-90% specific, with a lower sensitivity, but react only with the major antigenic determinants (allergy to minor determinants is tested by skin prick testing).
Antibodies with specific recognition for specific antigenic determinants could now be prepared.
The L segment encodes the RNA-dependent RNA polymerase; antigenic determinants are the M-encoded viral surface glycoproteins Gn and Gc, which are responsible for viral attachment, cell fusion, hemagglutination, and the induction of neutralizing antibodies, and the S-encoded nucleocapsid protein N, which plays a role in complement fixation (6).
The development of an antibody-based ELISA test to type haptoglobin has been hampered by the apparent lack of antigenic determinants unique to either allelic protein product.
Antibody responses to antigenic determinants of influenza virus hemagglutinin.
To compare with IAPP immunoreactivity measured by another assay detecting different antigenic determinants, the same samples were assayed by the solid amylin enzyme immunoassay (Amylin Pharmaceuticals Inc) without extraction (4).
This property is especially critical during human pandemics that are characterized by novel antigenic determinants.
To explain the low sensitivity, it must be considered that anti-CCP antibodies are a heterogeneous group of antibodies directed against different epitopes on the citrulline molecule, that each patient's serum contains different subsets of antibodies, and that the synthetic peptide used in this assay represents a relatively small set of antigenic determinants that do not entirely encompasses the antigenic determinants present on the as yet unknown antigenic molecule in the joint (14).
Rheumatoid factor, autoantibodies that bind to multiple antigenic determinants on the Fc portion of IgG.