antigenic determinant


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Related to antigenic determinant: hapten, Clonal selection

determinant

 [de-ter´mĭ-nant]
a factor that establishes the nature of an entity or event.
antigenic determinant a site on the surface of an antigen molecule to which a single antibody molecule binds; generally an antigen has several or many different antigenic determinants and reacts with many different antibodies. Called also epitope.
 Antigens contain antigenic determinants (epitopes) and antibodies contain antibody combining sites (paratopes). From Copstead and Banasik, 2000.
hidden determinant an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
immunogenic determinant the part of an immunogenic molecule that interacts with a helper T cell in triggering antibody production as opposed to the antigenic determinant or hapten, which interacts with B cells.

an·ti·gen·ic de·ter·mi·nant

the particular chemical group of a molecule that determines immunologic specificity.
Synonym(s): determinant group

antigenic determinant

a site on an antigen molecule to which an antibody molecule binds. Also called epitope.

an·ti·gen·ic de·ter·mi·nant

(an'ti-jen'ik dĕ-tĕr'mi-nănt)
The particular chemical group of a molecule that determines immunologic specificity.

antigenic determinant

A cluster of EPITOPES.

antigenic determinant

see EPITOPE.

determinant

a factor that establishes or changes the nature of an entity or event. The factor may be environmental, be a part of the host or its defenses, be single or multiple and be immediate or remote.

allotypic determinant
an antigenic determinant which varies among members of the same species.
antigenic determinant
a structural component of an antigen against which immune responses are made and to which antibody or T cell receptor binds; an antigen such as a protein has many antigenic determinants. Called also epitope.
disease d's
factors which affect the occurrence or rate of ocurrence of a disease.
hidden determinant
an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
isotypic determinant
one that occurs in all individuals of the same species.
References in periodicals archive ?
coli strain O157:H19), and the antiserum containing the common antigenic determinant "a" of F18ab and F18ac were provided by Yangzhou University, Yangzhou, China.
The RAYS ratios before and after denaturation and the overall distinction between linear and conformational antigenic determinants of the SARS-CoV N protein are shown in Fig.
Despite the extensive use of PSA as a clinical marker of prostate cancer, much is yet to be learned about the antigenic determinants on the PSA molecule (15).
These data suggest that the insulin lispro antigenic determinant comprises charge, steric, and secondary structural components.
Use of a gene-targeted phage display random epitope library to map an antigenic determinant on the bluetongue virus outer capsid protein VP5.
Lyme disease spirochetes and ixodid tick spirochetes share a common surface antigenic determinant defined by a monoclonal antibody.
RED BLOOD CELLS CONCENTRATE (SERASCAN) (vial presentation (I and II) with 10 ml of human erythrocytes group 0, with more significant antigenic determinants of most of the blood group systems.
Langerhans cells have cytoplasmic inclusion bodies known as Birbeck granules; a definitive diagnosis requires electron microscopy of Birbeck granules or CD 1 antigenic determinants by immunohistochemistry.