antigen-presenting cell


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Related to antigen-presenting cell: dendritic cell, T cell

antigen-presenting cell

a cell that can break down protein antigens into peptides and present the peptides, in conjunction with major HLA complex class II molecules, on the cell surface, where they can interact with T cell receptors. Macrophages are one type of antigen-presenting cell.

antigen-presenting cell

Abbreviation: APC
A cell that breaks down antigens and displays their fragments on surface receptors next to major histocompatibility complex molecules. This presentation is necessary for some T lymphocytes that are unable to recognize soluble antigens. Macrophages are the primary antigen-presenting cells, but B cells and dendritic cells also can act as APCs.
See: T cell; macrophage processing cell
See also: cell

antigen-presenting cell

A cell, such as a macrophage, a B cell or a dendritic cell, that presents processed antigenic peptides and MHC class II molecules to the T cell receptor on CD4 T cells.
References in periodicals archive ?
Chakraborty proposed that the chain of events that led a T cell to go forth and conquer involved a type of hysteresis; the response to signals from antigen-presenting cells was based on recent encounters with other antigen-presenting cells.
If the antigen-presenting cells produce the peanut protein robustly enough, the responsibility for the immune response might shift away from the IgE antibodies and mast cells.
This study showed that the cigarette recruited antigen-presenting cells (cells that orchestrate the immune system's response to antigens) as co-conspirators in the lung-destroying crime, using specific genes that regulate proteins in their deadly role.
The dynamics of helper and suppressor T cells and their interaction with antigen-presenting cells could be modeled as a separate subsystem, or module, whose output served as input to the B-cell module.
The active immunotherapy approach many immunologists see as most promising involves using antigen-presenting cells to induce tumor-specific T-cell responses in melanoma patients.
Scientists consider dendritic cells to be the most potent antigen-presenting cells in the body.
A number of activated immune cells can infiltrate the synovium (including CD4+ T-cells, B-cells and antigen-presenting cells such as dendritic cells and macrophages).
APX005M, a novel, humanized monoclonal antibody that stimulates the anti-tumor immune response in the tumor microenvironment through antigen-presenting cells of the immune system, is engineered to selectively activate CD40 in tumor tissues, rather than broadly in the bloodstream like other CD40 agonists.
Immune cells known as antigen-presenting cells need to activate T lymphocytes to trigger them to attack, but in cancer, cells called tumor-associated macrophages tell T lymphocytes to remain dormant, and also foster the development of blood vessels that feed the growing tumor.
ADXS-HPV is designed to infect antigen-presenting cells and direct them to generate a powerful, cellular immune response to HPV E7, concluded the company.
The researchers found that one TLR, known as TLR8, triggered a strong immune response in antigen-presenting cells, which are crucial for vaccine responses.
CTLA4Ig binds to CD80 and CD86 on antigen-presenting cells, blocking the engagement of CD28 on T cells and preventing T-cell activation.