antigen-presenting cell


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Related to antigen-presenting cell: dendritic cell, T cell

antigen-presenting cell

a cell that can break down protein antigens into peptides and present the peptides, in conjunction with major HLA complex class II molecules, on the cell surface, where they can interact with T cell receptors. Macrophages are one type of antigen-presenting cell.

antigen-presenting cell

Abbreviation: APC
A cell that breaks down antigens and displays their fragments on surface receptors next to major histocompatibility complex molecules. This presentation is necessary for some T lymphocytes that are unable to recognize soluble antigens. Macrophages are the primary antigen-presenting cells, but B cells and dendritic cells also can act as APCs.
See: T cell; macrophage processing cell
See also: cell

antigen-presenting cell

A cell, such as a macrophage, a B cell or a dendritic cell, that presents processed antigenic peptides and MHC class II molecules to the T cell receptor on CD4 T cells.
References in periodicals archive ?
However, in July, he and his colleagues described a molecule they believe can deliver the gene straight to the antigen-presenting cells.
Using conditions similar to those currently being evaluated in clinical trials, the researchers showed that electroporation increased numbers of antigen-presenting cells at the site of administration that correlated with increases in antibody titers and T-cell responses to the encoded antigen.
The immune system is able to recognize tumor antigens through the activity of professional antigen-presenting cells (APCs).
The antibody inhibits the binding of the B7-1 ligand on antigen-presenting cells to the CD28 receptor on T cells, thus blocking the second signal for inflammatory T-cell activation.
The interim results of the study suggest that intradermal administration of CDX-1307 results in localization of Beta subunit of human chorionic gonadotropin (Beta hCG) in antigen-presenting cells of the skin.
The immune system is able to recognize tumor antigens through the activity of professional antigen-presenting cells, called dendritic cells, which capture and process the tumor antigen.
This research demonstrates that these generated progenitor cells can be efficiently converted to highly pure populations of autologous ("self") antigen-presenting cells (dendritic cells) which may prove clinically useful in various immune cell-based vaccination strategies for the treatment of infectious diseases and malignancies.
IDEC-114 has the potential to selectively regulate the immune response by binding to CD80 (anti-B7), a key co-stimulatory molecule on antigen-presenting cells.
IDEC-114 has the potential to selectively regulate the immune response by binding to CD80, a key co-stimulatory molecule on antigen-presenting cells.
IDEC-131 targets a key pathway in the immune system -- the CD154-CD40 pathway -- that involves collaboration between T cells and B cells, as well as other antigen-presenting cells.
Furthermore, we have the ability to selectively target our highly compacted DNA particles by attaching cell-specific ligands, including ligands specific to antigen-presenting cells.