interferon gamma

(redirected from antigen interferon)
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in·ter·fer·on gam·ma

interferon elaborated by T lymphocytes in response to either specific antigen or mitogenic stimulation; only one gene codes for gamma interferon. interferon γ behaves like a biologic response modifies and is highly immunoregulatory.

interferon gamma

interferon gamma

a small, species-specific glycoprotein produced by mitogen-stimulated T cells. It possesses antiviral activity and plays a central role in the immunoregulatory processes.

IFNG

A gene on chromosome 12q14 that encodes a soluble cytokine belonging to the type-II interferon family that has antiviral, immunoregulatory and anti-tumour properties, and is a potent macrophage activator. It is produced by lymphocytes activated by specific antigens or mitogens.

Molecular pathology
Defects in IFNG is associated with increased susceptibility to aplastic anaemia in Caucasians.

interferon gamma

IFN-γ A 21-25 kD glycoprotein lymphokine encoded on chromosome 12q and produced by activated T and NK cells; IFN-γ is antiviral, regulates class II MHC antigen expression, Fc receptors and immunoglobulin production and class switching, activates monocyte cytotoxicity and enhances NK cell activity; IFN-γ is ↓ in IgA deficiency, lymphoma, CLL, infections–eg, CMV, EBV, rubella, lepromatous leprosy, TB, SLE, rheumatoid arthritis, sickle cell anemia, post-transplantation Indications Recombinant IFN-γ is used to treat condylomata acuminata, CLL, Hodgkin's disease, mycosis fungoides, rheumatoid arthritis, and possibly leprosy, TB, nontuberculous mycobacterial infections, toxoplasmosis, chronic granulomatous disease–to prevent infections; IFN-γ suppresses collagen synthesis by fibroblasts, ↓ the size of keloids, causing a local ↑ in inflammatory cells and mucin production, and may be of use in controlling abnormal fibrosing conditions Side effects Acute renal failure, rash, headache, chills

in·ter·fer·on gam·ma

(intĕr-fēron gamă)
That interferon elaborated by T lymphocytes in response to either specific antigen or mitogenic stimulation.
Synonym(s): antigen interferon, immune interferon.

interferon gamma

An INTERFERON used as an antiviral drug. A brand name is Immukin.

in·ter·fer·on gam·ma

(intĕr-fēron gamă)
Interferon elaborated by T lymphocytes in response to either specific antigen or mitogenic stimulation.