antigen excess


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an·ti·gen ex·cess

1. in a precipitation test, the presence of uncombined antigen in excess of that required to combine with all of the antibody; precipitation may be inhibited because the presence of excess antigen gives rise to soluble antigen-antibody complexes;
2. in vivo, the resultant antigen-antibody interaction in such an antigen excess may give rise to immune complexes, which have a potential to induce cellular damage; could be tolerogenic.

an·ti·gen ex·cess

(an'ti-jen eks'es)
1. In a precipitation test, the presence of uncombined antigen above that required to combine with all of the antibody.
2. In vivo, the resultant antigen-antibody interaction in such an antigen excess may give rise to immune complexes, which have a potential to induce cellular damage.
References in periodicals archive ?
The serum was retested with further dilutions to rule out antigen excess, and no antigen excess was detected.
In conclusion, we have illustrated that antigen excess can cause falsely low serum FLC results with nephelometric techniques.
The manufacturer assay protocol for total [kappa] did not include a prereaction step to detect antigen excess.
200 cutoff value for the prozone check effectively detected all samples in which antigen excess caused falsely low microalbuminuric or normal values.
We can recognize antigen excess by the appearance of two curved bands at the edges of an inner colorless zone indicating the excess antigen.
We used polyclonal free light chains to initially test for antigen excess and showed that the assay was robust.
The quoted upper limit for IgG before antigen excess is reached is 95 g/L.
The Access Hybritech PSA assay did not demonstrate antigen excess up to 50 000 [micro]g/L PSA, and FPSA did not hook until >20 000 [micro]g/L.