antifungal agents


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antifungal agents

topical and systemic agents used to treat skin and nail mycoses (Table 1) topical therapy is indicated for mild skin mycosis, but marked or severe onychomycosis requires systemic therapy; immunocompromised patients should receive prophylactic antifungal therapy
Table 1: Treatment of fungal infections of skin and nails
Infection siteAgent
Antimycotic agent (for the treatment of dermatophytosis)
SkinTopical allylamine (e.g. 1% terbinafine cream for 7 days)
Topical imidazoles (e.g. 2% miconazole or 1% clotrimazole for 28 days)
Topical 0.25% amorolfine
Topical 1% econazole
Topical griseofulvin spray (400 μg puff daily for 14 days)
Topical 1% sulconazole
Topical tea tree (manuka) oil
Topical undecenoate (20% zinc undecenoate + 5% undecenoic acid)
Topical Whitfield's ointment (6% benzoic acid + 3% salicylic acid)
Other topicals include: weak iodine solution 2.5%; potassium permanganate paint 1%; salicylate acid cream or alcoholic solution 3-5%; benzoic acid (Whitfield's) ointment; sodium polymetaphosphate dusting powder
Systemic terbinafine (250 mg daily for 2 weeks)
Systemic itraconazole (100 mg daily for 15 days)
Systemic griseofulvin (500 mg daily )
NailTopical amorolfine 0.25% lacquer as an adjunct to systemic treatment
Topical borotannic acid complex acid; Phytex paint (1.46% salicylic acid + 4.89% tannic acid + 3.12% boric acid)
Topical 28% tioconazole lacquer
Topical undecenoate lacquer; Monphytol paint (5% methyl undecenoate + 0.7% propyl undecenoate + 3% salicylic acid + 25% methyl salicylate + 5% propyl salicylate + 3% chlorambucil)
Other topicals: strong iodine 10% solution
Systemic terbinafine (250 mg daily for 12-16 weeks)
Systemic itraconazole (400 mg for 1 week in a month, repeated overall 3 or 4 times)
Anticandidal agent (for the treatment of candidiasis)
SkinTopical antimycotic creams (1% clotrimazole; 1% econazole; 2% miconazole)
Topical nystatin (100 000 units ± 1% tolnaftate)
Antipityriasis versicolor agent (for the treatment of pityriasis versicolor)
SkinTopical 2% ketoconazole
Topical 2.5% selenium sulphide
Topical antimycotic agents (1% clotrimazole; 1% econazole; 2% miconazole; 1% sulconazole; 1% terbinafine)
Systemic fluconazole/itraconazole/ketoconazole/miconazole/voriconazole

antifungal agents,

n.pl agents that inhibit, control, or kill fungi. The most common yeastlike fungus occurring in or near the oral cavity is
C. albicans.
References in periodicals archive ?
Contract notice: Antibiotics, antiviral and antifungal agents.
In response to this, various antifungal agents with novel action mechanisms, broader action spectrum and fewer side effects have emerged.
Further, most conventional antifungal agents do not completely destroy the fungi but merely inhibit their growth, which may lead to future infections.
The NOFUN project is a collaborative project under the 7th Framework Program of the European Commission which brings together five partners to accelerate the development of a number of F2G's broad spectrum antifungal agents.
Therefore, new therapeutic strategies using antifungal agents that originated from natural substances and also understanding the mechanisms of action of these drugs may be one way to develop more effective anticandicial agents.
We urgently need new classes of antifungal agents for Candida vaginitis," he said.
Because they have a variety of useful properties, especially as antibacterial and antifungal agents, silver nanoparticles increasingly are being used in a wide variety of industrial and consumer products.
Meanwhile, it has published a guideline on the clinical evaluation of antifungal agents for treating and preventing invasive fungal disease --http://www.
Luliconazole is one of the most potent and broad- spectrum topical antifungal agents in development and will be advancing to Phase 3 clinical development in the U.
To overcome these problems, attempts have been made to incorporate the antifungal agents such as Zinc undecylenate, Nystatin, Fluconazole and Itraconazole to the resilient liners.
Treatment options include local debridement, discontinuation of topical antibiotics, and the use of local or systemic antifungal agents.