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The concomitant use of pyrimethamine with other antifolic drugs or agents associated with myelosuppression including sulfonamides or trimethoprim-sulfamethoxazole combination, proguani, zidovudine, or cytostatic agents (e.
The major commercial application of this enzyme is in the hydrolysis of gallotannin to gallic acid, which is an intermediate required for the synthesis of an antifolic antibacterial drug trimethoprim (Sitting et al.