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antifolate chemotherapy |
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antifolate chemotherapy Antifolate therapy Oncology The use of an antimetabolite–eg, MTX, to compete with folate, inhibiting dihydrofolate reductase, the enzyme responsible for → inactive dihydrofolate into an active
tetrahydrofolate; this block causes a buildup of toxic dihydrofolate, shutting down synthesis of purine nucleotides and thymidylate; AC is used to treat malignancy. See Leukovorin rescue. Methotrexatre How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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