It can be attributed to the antiestrogenic
activity of BPA as estrogen is known to increase the excitability of myometrium.
Their name says it all, as phytoestrogens exhibit mild estrogenic and antiestrogenic
activity in the body.
Lack of estrogenic or antiestrogenic
actions of soy isoflavones in an avian model: The Japanese quail.
Arnold, The Estrogenic and Antiestrogenic
Activities of Phytochemicals with the Human Estrogen Receptors Expressed in Yeast.
3 The antiestrogenic
action of gestrinone, associated with its ability to reduce estradiol production by the ovary, may further inhibit endometrial proliferation in endometriosis and allow effective treatment of endometriosis-related pain.
The estrogenic and antiestrogenic
activities of phytochemicals with the human receptor expressed in yeast steroids, 62: 365-372.
Hansen, Estrogenic and antiestrogenic
actions of PCBs in the female rat: In vitro and in vivo studies", Reprod.
When tested in normal human mammary tissue explant cultures, ospemifene was also found to have antiestrogenic
, growth inhibitory effects, similar to raloxifene and tamoxifen.
Letrozole as an aromatase inhibitor induces ovulation in women with PCOS without having antiestrogenic
effects on the endometrium (10).
Resveratrol has the capability to act in an estrogenic or antiestrogenic
manner to inhibit or promote breast cancer progression, dependent on concentration, and can bind to and regulate gene transcription through estrogen receptor [alpha] and [beta] isoforms (6-8).
The phloretin glucoside phloridzin plays a role of phytoestrogen with estrogenic and antiestrogenic
activity (Wang et al.
The randomized, double-blind, phase II study compared transdermal application of a gel containing 4-hydroxytamoxifen (4-OHT), an antiestrogenic
metabolite of tamoxifen (4 mg/day), to oral tamoxifen (20 mg/day) in preand postmenopausal women with estrogen receptor--positive ductal carcinoma in situ (DCIS).