One study indicated that BPF was antiestrogenic
(Stroheker et al.
3,3'-diindolylmethane (DIM) is a compound found in cruciferous vegetables that has been well studied in breast, cervical, and thyroid cancers for its antiestrogenic
, positive estrogen metabolism effects.
Evaluation of estrogenic, antiestrogenic
and genotoxic activity of nemorosone, the major compound found in brown Cuban propolis.
Letrozole as an aromatase inhibitor induces ovulation in women with PCOS without having antiestrogenic
effects on the endometrium (10).
The randomized, double-blind, phase II study compared transdermal application of a gel containing 4-hydroxytamoxifen (4-OHT), an antiestrogenic
metabolite of tamoxifen (4 mg/day), to oral tamoxifen (20 mg/day) in preand postmenopausal women with estrogen receptor--positive ductal carcinoma in situ (DCIS).
4] and the use of adjuvant hormone therapy with antiestrogenic
agents, such as tamoxifen, to reduce the risk of recurrence.
The objective of this study was to investigate the antiestrogenic
activity of 3,3'-diindolylmethane (DIM), a bioactive compound derived from cruciferous vegetables, in patients with TPD.
Despite the fact that CSCs are not known to be ER positive, breast cancers have been successfully treated with antiestrogenic
Of all the isoflavones, genistein is still attracting the most attention because of its estrogenic and antiestrogenic
effects which, at high concentration, have shown inhibition on cancer cell lines through the modulation of the transforming growth factor (TGF) (Kim 1998).
15) ER expression is strongly predictive of response to antiestrogenic
Baron JA, La Vecchia C, Levi F The antiestrogenic
effect of cigarette smoking in women.
This difference suggests an antiestrogenic
effect of smoking among postmenopausal women that may further reduce their already low endogenous estrogen levels.