antiestrogen


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estrogen

 [es´tro-jen]
a generic term for any of the estrus-producing compounds (female sex hormones), including estradiol, estriol, and estrone. Called also estrogenic hormone. In humans, the estrogens are formed in the ovary, adrenal cortex, testis, and fetoplacental unit, and are responsible for female secondary sex characteristic development, and during the menstrual cycle, act on the female genitalia to produce an environment suitable for fertilization, implantation, and nutrition of the early embryo. Uses for estrogens include oral contraceptives, hormone replacement therapy, advanced prostate or postmenopausal breast carcinoma treatment, and osteoporosis prophylaxis.
conjugated e's a mixture of the sodium salts of the sulfate esters of estrone and equilin; therapeutic uses are similar to those of other estrogens; administered orally, intravenously, intramuscularly, or intravaginally.
esterified e's a mixture of esters of estrogenic substances, principally estrone, having therapeutic uses similar to those of other estrogens.

an·ti·es·tro·gen

(an'tē-es'trō-jen),
Any substance capable of preventing full expression of the biologic effects of estrogenic hormones on responsive tissues, either by producing antagonistic effects on the target tissue, as androgens and progestogens do, or by competing with estrogens at estrogen receptors at the cellular level (for example, tamoxifen).
Synonym(s): estrogen antagonist

antiestrogen

/an·ti·es·tro·gen/ (-es´tro-jen) a substance capable of inhibiting the biological effects of estrogens.antiestrogen´ic

antiestrogen

[-es′trəjən]
a hormone-based product used predominantly in cancer chemotherapy. The group of antiestrogen drugs includes tamoxifen. They are used mainly in treating estrogen-dependent tumors, such as breast cancer.

an·ti·es·tro·gen

(an'tē-es'trō-jĕn)
Any substance capable of preventing full expression of the biologic effects of estrogenic hormones on responsive tissues.
Synonym(s): antioestrogen.

antiestrogen

1. blocking the action of estrogens.
2. an agent that so acts.
References in periodicals archive ?
TABLE 23 SHARES OF MANUFACTURERS/DISTRIBUTORS FOR ANTIESTROGENS AND SELECTIVE ESTROGEN RECEPTOR MODULATORS, 2007 (%)
This multicenter randomized Phase 2 study will enroll approximately 90 women with advanced breast cancer whose disease had progressed on antiestrogen therapy.
Agent PK PD (IEB) Antiestrogens Tamoxifen +3 +4 (ER) Raloxifene +4 +4 (ER) Flutamide +2 +4 (AR) NSAI Ds Sulindac +3 +4 (Cox-1/2) R-Flurbiprofen +3 +4 (Cox-1/2) Retinoids 4-HPR +4 +4 (IGF-1, apoptosis) 9-cis-RA +4 +4 (RAR/RXR) 13-cis-RA +4 +4 (RAR/all-trans-RA) Selenium Se-methionine +3 +4 (GSH peroxidase) Dehydroepiandrosterone +4 +4 (Androgenic, estrogenic) Difluoromethylornithine +1 +4 (Polyamines) Agent Issue Antiestrogens Tamoxifen Endometrial CA (+) Raloxifene Endometrial (CA (-) Flutamide Gynecomastia NSAI Ds Sulindac GI toxicity R-Flurbiprofen R > S (anti-CA) Retinoids 4-HPR Night blindness (retinol concns.
2]- and BPA-induced insulin expression, we used mice treated with the antiestrogen ICI, as described for the experiment presented in Figure 2.
was approved in the United States in 1997 as a second-line therapy for treating advanced breast cancer in postmenopausal women with disease progression following antiestrogen therapy.
We found that the lower-chlorinated PCBs were estrogenic, whereas the prevalent higher-chlorinated PCB congeners 138, 153, 170, 180, 187, 194, 199, and 203, as well as major PCB metabolites, behaved as antiestrogens.
Current therapies include chemotherapy and hormone therapy, such as the antiestrogen tamoxifen.
This binding was unaffected in competitive assays using the pure antiestrogen ICI182,780, which inhibits only classical ER-mediated effects.
Femara is also indicated for the treatment of advanced breast cancer in postmenopausal women with disease progression following antiestrogen therapy.
Sexual preference and feminine and masculine sexual behavior of male rats prenatally exposed to antiandrogen or antiestrogen.