antiestrogen


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estrogen

 [es´tro-jen]
a generic term for any of the estrus-producing compounds (female sex hormones), including estradiol, estriol, and estrone. Called also estrogenic hormone. In humans, the estrogens are formed in the ovary, adrenal cortex, testis, and fetoplacental unit, and are responsible for female secondary sex characteristic development, and during the menstrual cycle, act on the female genitalia to produce an environment suitable for fertilization, implantation, and nutrition of the early embryo. Uses for estrogens include oral contraceptives, hormone replacement therapy, advanced prostate or postmenopausal breast carcinoma treatment, and osteoporosis prophylaxis.
conjugated e's a mixture of the sodium salts of the sulfate esters of estrone and equilin; therapeutic uses are similar to those of other estrogens; administered orally, intravenously, intramuscularly, or intravaginally.
esterified e's a mixture of esters of estrogenic substances, principally estrone, having therapeutic uses similar to those of other estrogens.

an·ti·es·tro·gen

(an'tē-es'trō-jen),
Any substance capable of preventing full expression of the biologic effects of estrogenic hormones on responsive tissues, either by producing antagonistic effects on the target tissue, as androgens and progestogens do, or by competing with estrogens at estrogen receptors at the cellular level (for example, tamoxifen).
Synonym(s): estrogen antagonist

antiestrogen

/an·ti·es·tro·gen/ (-es´tro-jen) a substance capable of inhibiting the biological effects of estrogens.antiestrogen´ic

antiestrogen

[-es′trəjən]
a hormone-based product used predominantly in cancer chemotherapy. The group of antiestrogen drugs includes tamoxifen. They are used mainly in treating estrogen-dependent tumors, such as breast cancer.

an·ti·es·tro·gen

(an'tē-es'trō-jĕn)
Any substance capable of preventing full expression of the biologic effects of estrogenic hormones on responsive tissues.
Synonym(s): antioestrogen.

antiestrogen

1. blocking the action of estrogens.
2. an agent that so acts.
References in periodicals archive ?
The tumor microenvironment has been suggested as a major factor in conferring innate resistance to cancer therapies (1), whereas a large proportion of patients develop resistance while receiving systemic antiestrogens such as tamoxifen or estrogen deprivation therapies such as aromatase inhibitors (AIs) (2-5).
In the present study, we investigated whether this transactivation is lost in the presence of a pure antiestrogen ICI 182,780.
Reversal of the estrogen receptor--negative phenotype in breast cancer and restoration of antiestrogen response
To investigate whether the effects are exclusively mediated by ER activation, cells were incubated with the effective doses of the test substances in the absence or presence of a 500 nM concentration of the pure antiestrogen ICI 182 780.
Common side effects for these chemotherapy antiestrogen drug inclue fatigue, vaginal discharge, hot flashes and mood swings.
If you prefer not to take estrogen, there are alternatives: three bisphosphonates, alendronate (Fosamax and Novo-alendronate), etidronate (Dodrocal) and risedronate (Actonel); and an antiestrogen (selective estrogen receptor modifier, or SERM) raloxifene (Evista).
This finding cannot be readily dismissed because estrogens play a role in maintaining normal mental functions, and it is possible that too much antiestrogen in the wrong place at the wrong time could be harmful.
16) Antiestrogen drugs such as tamoxifen and testolactone have been used in selected cases with success.
Tamoxifen citrate is a nonsteroidal antiestrogen used in the treatment of breast cancer.
Tamoxifen is an antiestrogen drug that works by blocking estrogen in the breast, thereby slowing the growth and reproduction of breast cancer cells that depend on estrogen for survival.