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antidiuretic |
Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia, Hutchinson | 0.02 sec. |
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antidiuretic /an·ti·di·uret·ic/ (-di?u-ret´ik) 1. pertaining to or causing suppression of urine. 2. an agent that so acts.
antidiuretic 1. pertaining to or causing suppression of urine production. 2. an agent that causes suppression of urine production. antidiuretic hormone vasopressin; a polypeptide hormine from the posterior lobe of the pituitary that suppresses the production of urine; it has a specific effect on the epithelial cells of the renal tubules, stimulating the reabsorption of water independently of solids, and resulting in concentration of urine. Stored and released by the posterior lobe of the pituitary gland, it also has vasopressor activity. Called also ADH. antidiuretic hormone response test measures urine specific gravity or osmolality before and after the administration of vasopressin to determine whether a polyuric condition is caused by a deficiency or reduced responsiveness to antidiuretic hormone. Called also Pitressin tannate test, Pitressin concentration test. syndrome of inappropriate secretion of antidiuretic hormone (SIADH) one in which there is abnormal production of ADH leading to hyponatremia (see also syndrome of inappropriate secretion of antidiuretic hormone). |
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Physuline is an oral vasopressin V2-receptor antagonist drug that has proven effective in patients with syndrome of inappropriate antidiuretic hormone (SIADH), a condition resulting in fluid overload due to the excessive release of antidiuretic hormone. Current views maintain that the role of hormones in the salivary glands--particularly aldosterone and antidiuretic hormone is solely to modify the ionic content of the saliva. This is due to two factors: 1) all such drinks are hypotonic (<135 mmol/L), and therefore will cause dilution of serum [Na+] if water is retained in the body to excess; and 2) it is well known that even administration of isotonic saline will not increase serum [Na+] in hyponatremic patients with the syndrome of inappropriate antidiuretic hormone secretion (SIADH) because in a euvolemic or hypervolemic state, the infused sodium will be excreted in the urine rather than retained (65). |
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antidiuretic
