The other Cochrane review, published in November 2017, concluded that insulin and oral antidiabetic
agents have similar effects on key health outcomes, and that each one has minimal harms.
The results of the antidiabetic
tests are presented in Table 3 and Figure 1.
To study the efficacy of bromocriptine mesylate as an add-on therapy in patients with T2DM inadequately controlled on two oral antidiabetic
Apparao, Evaluation of Antidiabetic
Effect of Momordica cymbalaria Fruit in Alloxan- Diabetic Rats, Fitoterapia, 74, 7 (2003).
Review of literature did not reveal any study that had evaluated the antidiabetic
potential of combined pomegranate peel with insulin sensitizer drug rosiglitazone.
Clinical and biochemical data included random plasma glucose level, duration of diabetes, family history of diabetes, co-morbidities and antidiabetic
Moreover, stem cell transplantation combined with currently available antidiabetic
drugs resulted in rapid weight loss in the mice and more significant improvements in glucose metabolism compared with either treatment alone.
Women who required antidiabetic
treatment were diagnosed a mean of 4 weeks earlier than those who did not (23 vs.
These chemicals are intrinsically used for medicinal purpose to treat different ailments including wound healing, anti-mycotoxic, antidiabetic
, antioxidant, anticonvulsant, antiulcer, antimicrobial and antiasthmatic activity (Pande and Anupam, 2010; Azmi et al.
2008) with fasting glucose levels above 200 mg/dl were administered daily with 1 or 2 (50 mg/kg), metformin (120 mg/kg) and vehicle (tween 80 10%, 1 ml) during 10 days; plasmatic glucose concentrations was monitored 24 h after administration at days 1, 3, 5, 8, and 10 to establish antidiabetic
Sreekumar has contributed in elephant physiology, avian physiology, endocrinology, haematology,stress physiology and management, physiological effects of medicinal plants, growth and antidiabetic
effect of natural molecules, mitigation of stress in chicken and promotion of growth using natural molecules, use of alternate feed source to reduce feed cost, improve production and mitigate pollution in birds and development of diabetic animal models and study the use of plant extracts as antidiabetic
and antilipidemic drugs.
Unpublished data suggest that a class of antidiabetic
drugs known as incretin mimetics may raise the risk of pancreatitis and precancerous changes (metaplasia) in the pancreatic duct in patients with type 2 (non-insulin-dependent) diabetes.