Department of Health and Human Services (HHS) to develop, test and manufacture a monoclonal antibody therapy
for the treatment of Ebola virus infection.
You see trends for these areas: -- Antibody-drug conjugates (ADCs) -- Engineered antibodies -- Bispecific antibodies -- Antibody fragments and antibody-like proteins (ALPs) -- Other progress in next-generation antibody therapy
This DuoBody plan is utilized for bringing out as well as formulate new bispecific antibodies which may enhance antibody therapy
of cancer, autoimmune, infectious and central nervous system disease, in addition it also renders bispecific antibodies with a fast and broadly applicable process which is easily performed at standard bench, as well as commercial, manufacturing scale.
The SBIR grant will fund a project entitled "The Creation of a Human Recombinant Polyclonal Antibody Therapy
Dr Wayne Marasco, of Harvard Medical School in Boston, found antibody therapy
provides a new way of fighting the disease.
Founded in 2000 by Ian Tomlinson and Sir Gregory Winter, Domantis has pioneered the next generation of antibody therapy
, which is based on the smallest functional binding units of human antibodies.
There is potential for a better overall response when these agents are combined with monoclonal antibody therapy
Several groups of scientists are now studying whether a few days or weeks of antibody therapy
, if given soon after diagnosis of type 1 diabetes, can keep the disease from worsening.
Research into fields such as functional cell therapy, anti-infective vaccines, metabolic disease treatment, cerebral disease treatment and monoclonal antibody therapy
are expected to benefit.
The company notes it has an agreement with an unnamed major clinical institute of transplantation to begin studies on the use of the antibody therapy
to stop organ rejection.
The objective of the company is to build a long-term dominant position within the field of polyclonal antibody therapy
Its preferential expression by cancer tissues makes it an ideal target for antibody therapy
, as the antibodies are unlikely to bind to and destroy normal tissues.