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affinity
(redirected from antibody affinity)

   Also found in: Dictionary/thesaurus, Legal, Encyclopedia, Wikipedia 0.01 sec.
affinity /af·fin·i·ty/ (ah-fin´ĭ-te)
1. attraction; a tendency to seek out or unite with another object or substance.
2. in chemistry, the tendency of two substances to form strong or weak chemical bonds forming molecules or complexes.
3. in immunology, the thermodynamic bond strength of an antigen-antibody complex. Cf. avidity.

af·fin·i·ty (-fn-t)
n.
1. An attraction or force between particles that causes them to combine.
2. The attraction between an antigen and an antibody.
3. A relationship or resemblance in structure between species that suggests a common origin.
4. The selective staining of a tissue by a dye.
5. The selective uptake of a dye, chemical, or other substance by a tissue.

affinity
[əfin′itē]
Etymology: L, affinis, related
the measure of the binding strength of the antigen-antibody reaction.

affinity [ah-fin´ĭ-te]
1. attraction; a tendency to seek out or unite with another object or substance.
2. in chemistry, the tendency of two substances to form strong or weak chemical bonds forming molecules or complexes.
3. in immunology, the thermodynamic bond strength of an antigen-antibody complex.

affinity
1. attraction; a tendency to seek out or unite with another object or substance.
2. in chemistry, the tendency of two substances to form strong or weak chemical bonds forming molecules or complexes.
3. in immunology, the thermodynamic bond strength of an antigen-antibody complex.

antibody affinity
the strength of the binding interaction between antigen and antibody.
drug affinity
the attraction of a particular class of receptor to a drug, at a level sufficient to give an observable reaction. Such a drug is an agonist.
affinity maturation
the increased affinity of antibody for an antigen which occurs during the course of an immune response.


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Hyper Mutation This is equivalent to the normal genetic mutation operator, except that the mutation ratio and values are chosen proportional to the antibody affinity, i.
12,13) Traditional methods for measuring antibody affinity or avidity are cumbersome; however, inclusion of a chaotropic agent to dissociate low-avidity antibodies in an EIA can provide avidity information in a simple assay.
Under a collaboration agreement Merck established with Abmaxis in late 2004, Abmaxis successfully re-engineered a Merck human monoclonal antibody and improved antibody affinity more than 70-fold while retaining its specificity.
 
 
 
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