antiandrogen

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androgen

 [an´dro-jen]
any steroid hormone that promotes male secondary sex characters. The two main androgens are androsterone and testosterone. Called also androgenic hormone. adj., adj androgen´ic. 

The androgenic hormones are internal endocrine secretions circulating in the bloodstream and manufactured mainly by the testes under stimulation from the pituitary gland. To a lesser extent, androgens are produced by the adrenal glands in both sexes, as well as by the ovaries in women. Thus women normally have a small percentage of male hormones, in the same way that men's bodies contain some female sex hormones, the estrogens. Male secondary sex characters include growth of the beard and deepening of the voice at puberty. Androgens also stimulate the growth of muscle and bones throughout the body and thus account in part for the greater strength and size of men as compared to women.
androgen insensitivity syndrome complete androgen resistance.

an·ti·an·dro·gen

(an'tē-an'drō-jen),
Any substance capable of preventing full expression of the biologic effects of androgenic hormones on responsive tissues, either by producing antagonistic effects on the target tissue, as estrogens do, or by merely inhibiting androgenic effects, such as by competing for binding sites at the cell surface.

antiandrogen

/an·ti·an·dro·gen/ (-an´dro-jen) any substance capable of inhibiting the biological effects of androgens.

antiandrogen

(ăn′tē-ăn′drə-jən, ăn′tī-)
n.
A substance that inhibits the biological effects of androgenic hormones.

antiandrogen

Endocrinology A hormone or other agent–eg, megestrol acetate, spironolactone, flutamide, nilutamide, and cimetidine, which interferes with androgen function by competitively inhibiting androgen binding to cognate receptors at the target organ and is either biologically inert or functionally very weak; these compounds are used to manage androgen-dependent CAs–♂ breast and prostate, hirsutism, acne

Antiandrogen

A substance that blocks the action of androgens, the hormones responsible for male characteristics. Used to treat prostate cancers that require male hormones for growth.
Mentioned in: Prostate Cancer

antiandrogen

any substance capable of inhibiting the biological effects of androgenic hormones.
References in periodicals archive ?
Antiandrogenic effects of bisphenol A and nonylphenol on the function of androgen receptor.
Administration of antiandrogenic caused a significant decrease in the protein concentration of epididymis, which was restored to normal levels after testosterone therapy (Brooks and Higgins, 1980).
In addition, experimental evidence suggests that some PCBs may exert estrogenic and possibly antiandrogenic effects and induce cytochrome p450 activity (McFarland and Clarke 1989; Wolff et al.
Some of these can act specifically on the reproductive system having estrogenic, anti-estrogenic, androgenic, and antiandrogenic activity.
Antiandrogenic therapy can cause coronary arterial disease.
The risk of hypoadrenalism is small, but ketoconazole has antiandrogenic effects and may cause gynecomastia and decreased libido in men.
Antiandrogenic Effects of Environmental Endocrine Disruptors.
The unique antiandrogenic property of drospirenone, found in YAZ, creates a functional blockage of male sex hormones that can be a cause of acne," said Dr.
Studies in human cell lines indicated that the two oils had oestrogenic and antiandrogenic activities.
It is an extract of the American dwarf palm tree and is thought to cause cholestatic hepatitis through both estrogenic and antiandrogenic effects.