Members of the phenanthroindolizidine alkaloid class are known to exhibit pronounced cytotoxicity and antiamebic
, antifungal, antibacterial, and anti-inflammatory activities and to also inhibit enzymes involved in the synthesis of DNA and proteins, and several alkaloids and their N-oxides (32-35) were obtained from the extract of F.
Retrospectively, the ineffectiveness of antibiotics and antiamebic
drugs suggested an unusual infection.
In that case an early diagnosis of PAM was made via an astute technician's visualization of ameba on a wet-mount of CSF, and aggressive antiamebic
therapy was started promptly.
Oral immunization with attenuated vaccine strains of Vibrio cholerae expressing a dodecapeptide repeat of the serine-rich Entamoeba histolytica protein fused to the cholera toxin B subunit induces systemic and mucosal antiamebic
Oral immunization with an attenuated vaccine strain of Salmonella typhimurium expressing the serine-rich Entameba histolytica protein induces an antiamebic
immune response and protects gerbils from amebic liver abscess.
antibodies to E histolytica appear in patients who develop invasive amebiasis.
histolytica and be treated unnecessarily with antiamebic
Many cases were misdiagnosed as amebiasis, and treatment with antiamebic
drugs contributed to the high mortality (2,3).