Members of the phenanthroindolizidine alkaloid class are known to exhibit pronounced cytotoxicity and antiamebic
, antifungal, antibacterial, and anti-inflammatory activities and to also inhibit enzymes involved in the synthesis of DNA and proteins, and several alkaloids and their N-oxides (32-35) were obtained from the extract of F.
In that case an early diagnosis of PAM was made via an astute technician's visualization of ameba on a wet-mount of CSF, and aggressive antiamebic
therapy was started promptly.
Oral immunization with attenuated vaccine strains of Vibrio cholerae expressing a dodecapeptide repeat of the serine-rich Entamoeba histolytica protein fused to the cholera toxin B subunit induces systemic and mucosal antiamebic
Oral immunization with an attenuated vaccine strain of Salmonella typhimurium expressing the serine-rich Entameba histolytica protein induces an antiamebic
immune response and protects gerbils from amebic liver abscess.
antibodies to E histolytica appear in patients who develop invasive amebiasis.