Recent guidelines from the World Gastroenterological Association (WGA) recommend that serologic testing including anti-tTG
and/or anti-EMA, or anti-DGP are required for diagnosis of CD.
All of the patients had anti-tTG
IgA antibody titres.
003 * Abbreviations: AGA, antigliadin antibodies; ALT, alanine transaminase; TgAb, anti-thyroglobulin antibodies; TPOAb, antithyroid peroxidase antibodies; anti-tTG
, antitissue transglutaminase antibodies; AST, aspartate aminotransferase; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; FT4, free thyroxin; GGT, [gamma]-glutamyltransferase; IQR, interquartile range; TBIL, total bilirubin; TSH, thyroid-stimulating hormone.
A 2013 Belgian prospective study of 104 non-IgA-deficient adults and children diagnosed with celiac disease and 537 adults and children without celiac disease evaluated the accuracy of 4 manufacturers' serologic tests for IgA anti-tTG
antibody, normal range as determined by the manufacturer was 9 - 11 U/mL.
We conducted this study to look at the pattern of clinical presentation of CD in our children, screen suspected cases of CD by IgA anti-tTG
antibodies, place patients with titers Greater than 30u/ml on GFD and observe the effect of GFD on anti-tTG
titers in our setup.
antibodies are highly sensitive and specific for the diagnosis of CD.
6) Currently, anti-TTG
IgA is used as the primary antibody in the diagnosis of celiac disease.
should be ordered in the following individuals:
8,23-25) When IgA deficiency exists, serological testing using IgG class EMA and anti-tTG
are recommended to be measured.
14) Patients with an IgA deficiency should be screened for celiac disease with a reliable anti-tTG
The IgA anti-tTG
provides the best specificity and is widely used.