anti-tTG

anti-tTG

The serum antitissue transglutaminase antibody. Patients with celiac disease have elevated levels of anti-tTG.
References in periodicals archive ?
Recent guidelines from the World Gastroenterological Association (WGA) recommend that serologic testing including anti-tTG and/or anti-EMA, or anti-DGP are required for diagnosis of CD.
All of the patients had anti-tTG IgA antibody titres.
003 * Abbreviations: AGA, antigliadin antibodies; ALT, alanine transaminase; TgAb, anti-thyroglobulin antibodies; TPOAb, antithyroid peroxidase antibodies; anti-tTG, antitissue transglutaminase antibodies; AST, aspartate aminotransferase; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; FT4, free thyroxin; GGT, [gamma]-glutamyltransferase; IQR, interquartile range; TBIL, total bilirubin; TSH, thyroid-stimulating hormone.
A 2013 Belgian prospective study of 104 non-IgA-deficient adults and children diagnosed with celiac disease and 537 adults and children without celiac disease evaluated the accuracy of 4 manufacturers' serologic tests for IgA anti-tTG.
For anti-tTG antibody, normal range as determined by the manufacturer was 9 - 11 U/mL.
We conducted this study to look at the pattern of clinical presentation of CD in our children, screen suspected cases of CD by IgA anti-tTG antibodies, place patients with titers Greater than 30u/ml on GFD and observe the effect of GFD on anti-tTG titers in our setup.
The anti-tTG antibodies are highly sensitive and specific for the diagnosis of CD.
6) Currently, anti-TTG IgA is used as the primary antibody in the diagnosis of celiac disease.
Anti-TTG should be ordered in the following individuals:
8,23-25) When IgA deficiency exists, serological testing using IgG class EMA and anti-tTG are recommended to be measured.
14) Patients with an IgA deficiency should be screened for celiac disease with a reliable anti-tTG IgG assay.
The IgA anti-tTG provides the best specificity and is widely used.