anti-neutrophilic cytoplasmic antibodies

anti-neutrophilic cytoplasmic antibodies

One of two (or three, if including x-ANCA) different IgG antibodies seen in patients with autoimmune diseases and ANCA-related vasculidites.

ANCA types
▪ c-ANCA (Cytoplasmic) (classic)—Autoantibodies against proteinase 3; diffuse cytoplasmic staining; seen in Wegener’s granulomatosis.
▪ p-ANCA (Protoplasmic)—Autoantibodies against myeoperoxidase; perinuclear staining; seen in ulcerative colitis, Churg-Strauss syndrome, primary sclerosing cholangitis, polyarteritis nodosa (microscopic polyangiitis variant), focal necrotising and crescentic glomerulonephritis, rheumatoid arthritis.
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The rest of the laboratory data was essentially unremarkable, including serum complement levels, anti-neutrophil cytoplasmic antibody, anti double-stranded DNA, human immunodeficiency virus, hepatitis serology, anti-phospholipid antibodies, anti-glomerular basement membrane antibody, and anti-neutrophilic cytoplasmic antibodies.
Pitfalls of formalin fixation for determination of anti-neutrophilic cytoplasmic antibodies.