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mül·le·ri·an in·hib·it·ing sub·stance (MIS),
a 535-amino acid glycoprotein secreted by the Sertoli cells of the testis. It is related to inhibin.
AMHA gene on chromosome 19p13.3 that encodes anti-Müllerian hormone, a member of the transforming growth factor-beta gene family, which mediates male sexual differentiation. AMH causes regression of Müllerian ducts, which would otherwise differentiate into the uterus and fallopian tubes.
AMH mutations result in persistent Müllerian duct syndrome.
müllerian inhibiting substanceA 59 kD glycosylated preproprotein of the TGF-beta family encoded by AMH on chromosome 19p13.3 and produced by Sertoli cells in the prepubertal testes, which promotes müllerian duct involution during normal male sexual differentiation. The lack of MIS results in persistent müllerian duct syndrome.
the factor secreted by the Sertoli cells of the embryonic, developing testis that causes regression of the müllerian ducts, the primordia for the accessory sex glands of the female.