anti-VEGF drugs


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anti-VEGF drugs 

Drugs which bind to VEGF receptors without causing activation, thus blocking the production of new blood vessels and enhanced vessel permeability by the vascular endothelial growth factor (VEGF). They are used in the treatment of some forms of cancer (administered intravenously), and injected intravitreally in the treatment of choroidal neovascularization, retinal venous occlusion, and macular oedema. Examples: bevacizumab, pegaptanib sodium, ranibizumab. Syn. angiogenesis inhibitors. See age-related macular degeneration; diabetic retinopathy; VEGF.
References in periodicals archive ?
According to data in the IRIS Registry, there is no statistically significant difference between endophthalmitis rates for injections of compounded anti-VEGF drugs used "off label" for wet age-related macular degeneration and those manufactured specifically for that purpose.
Laser surgery, injection of corticosteroids or anti-VEGF drugs into the eye, and vitrectomy are some of the available treatments.
By the mid 2000s with the discovery of the role of VEGF in the development of CNVM, new categories of anti-VEGF drugs appeared and have become the standard of care.
Instead, in 2001, Jain proposed doing the opposite: increasing a tumor's blood supply and repairing leaky blood vessels with anti-VEGF drugs used in judicious doses.
Its off-label use has been controversial mainly because two other anti-VEGF drugs are on the market, but at very much higher prices that would put them out of reach of poorer patients.
Only those patients who had already gone blind in one eye would be eligible for anti-VEGF drugs Macugen and Lucentis.
She needs anti-VEGF drugs to save her sight but the Dorset Trust has not yet provided the drugs, saying it has yet to formulate a policy for the treatment.
It is also notable that DCE-MRI results appear to show an anti-VEGF effect with ALN-VSP in approximately 50% of evaluable patients, including those who have been previously exposed to anti-VEGF drugs.
Beyond anti-VEGF drugs, the wet AMD pipeline is headed by Ophthotech Corporation's Fovista, a PDGF-B blocker which achieved high efficacy results in phase II as part of a combination therapy.
He plans to conduct such assessments in eye-disorder patients--who typically receive direct injections of anti-VEGF drugs to their eyes--to determine whether the drugs are causing any adverse side effects.
The main reason for the controversy created by the off-label use of Avastin is that there are anti-VEGF drugs on the market that have formal approval for the treatment of AMD (and other eye conditions).
Nice (The National Institute for Clinical Excellence) has not yet given formal guidance on the anti-VEGF drugs, although they are available for use on the NHS if PCTs decided to fund them, says the Royal National Institute of the Blind.