anti-Scl-70

anti-Scl-70

Anti-scleroderma or anti-topoisomerase I antibody Immunology An autoantibody that occurs in Pts with scleroderma. See Scleroderma.
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Among the anti-ENA autoantibody subtypes, anti-ACA was seen in 37% of patients, anti-Scl-70 in 24%, anti-RNP in 9%, and anti-RNAPIII in 5%; other subtypes were rarer.
All the patients' sera were analyzed for the anti-SmD1[sub]83-119, anti-Sm, anti-U1-nRNP, anti-double-stranded DNA (dsDNA), anti-nucleosome, anti-SSA/Ro60, anti-SSA/Ro52, anti-SSB, anti-Scl-70, and anti-histone antibodies using the immunoblotting assay.
0 Diffuse/limited 12/53 Raynaud's phenomenon (+/-) 60/5 Anti-centromere 24/41 antibodies (+/-) Anti-Ro/SSA antibodies (+/-) 15/50 Anti-La/SSB antibodies (+/-) 4/61 Anti-Scl-70 antibodies (+/-) 19/46 Antinuclear antibodies (+/-) 62/3 Disease duration (years) 8.
2) The presence of either anticentromere antibodies (ACA) or anti-Scl-70 is highly specific (95%-99%) for the diagnosis of ISSc and dSSc, respectively.
ANA anti dsDNA anti LKM Anti-SMA AMA C-ANCA P-ANCA anti-SSA anti-SSB anti-Scl-70 anti Jo-1 anti-U1snRNP anti- centromere anti-Jo-1 anti tpo and anti tg were studied in all individuals in each study group.
Anticardiolipin, anticentromere and anti-Scl-70 antibodies in patients with systemic sclerosis and severe digital ischaemia.
She was negative for Anti-SSA/SSB, Anti-DNA, Anti-sm, Anti-nRNP, Anti-Jo-1, Anti-histone, and Anti-Scl-70.
The presence of taut, thin skin causing contractures; Raynaud phenomenon; esophageal dysmotility; restrictive lung disease; and the autoantibodies anticentromere and anti-Scl-70 is used to further confirm and distinguish different subtypes of systemic sclerosis.
ANA, anti-ds-DNA, anti-La, anti-Sm, anti-Scl-70, anti-Jo, anti-histon antikorlari ile anti-HIV ve anti-HCV antikorlari negatif olarak elde edildi).
The laboratory tests performed for the differential diagnosis were all negative (vitamin B12, anti-HIV, VDRL-RPR/TPHA, protein C, protein S, antithrombin III, lupus anticoagulants, factor V Leiden mutation, anti-histone ab, antinucleosome ab, anti-Sm ab, anti-U1 snRNP ab, anti-SS-A ab, antiSS-B ab, anti-Scl-70, anti-centromere ab, anti-Jo1 ab, ANA, anti-ds DNA, anti-cardiolipin ab IgM and IgG).
Binding of anti-Scl-70 to chromatin (6) and the patient's ethnic background may also account for these differences.