BL22

(redirected from anti-CD22 immunotoxin)
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BL22

A 63-kDa anti-CD22 recombinant immunotoxin, containing truncated Pseudomonas exotoxin and variable domains from an anti-CD22 antibody. It was effective against hairy cell leukaemia in phase-II trials of patients who had relapse less than 4 years after cladribine therapy.
References in periodicals archive ?
Complete remissions in 3 of 12 patients with chemotherapy-refractory pediatric acute lymphoblastic leukemia (ALL) during phase I testing of the anti-CD22 immunotoxin moxetumomab pasudotox (CAT-8015)- presented by Dr.
In 2004, the company decided to focus its therapeutic activities on oncology and in December of that year in-licensed two anti-CD22 immunotoxin programs from the National Cancer Institute (NCI) -- GCR-3888 and GCR-8015.
Cytotoxicity of the anti-CD22 immunotoxin HA22 against pediatric acute lymphoblastic leukemia (ALL) (Poster Session: Pediatric Brain Tumors and Leukemia, abstract 4356, poster section 19) - Tuesday, April 20 from 2:00 p.