anthracenedione

anthracenedione

 [an″thrah-sēn-di´ōn]
any of a class of derivatives of anthraquinone; some have antineoplastic properties; the group includes mitoxantrone hydrochloride.

anthracenedione

/an·thra·cene·di·one/ (an″thrah-sēn-di´ōn) any of a class of derivatives of anthraquinone, some of which have antineoplastic properties.
References in periodicals archive ?
HPLC analysis showed the 9,10- anthracenedione and 1-hydroxy-4-methylanthaquinone standards eluted at retention times of 5.
Concentration of the identified anthraquinones in elicited and control cultures Anthraquinone Control Control (supernatant (intracellular extract) extract) 9,10- Co-elution Co-elution anthracenedione 2-methyl -- 0.
Examples of drugs containing the 9, 10- anthracenedione moiety include: doxorubicin and mitoxantrone (McClendon and Osheroff 2007).
Thin layer chromatography was performed to detect anthraquinones in cell and supernatant extracts by using of 9,10- anthracenedione and 1-hydroxy-4methylanthaquinone standards (1 mg x [ml.
Pixantrone, the Company s clinical trial product for the treatment of non-Hodgkin s lymphoma and other hematologic malignancies, and solid tumors, is the first aza-anthracenedione to reach advanced clinical development, and was designed to improve the efficacy, and reduce the toxicity, associated with anthracyclines and anthracenediones.
Multidrug resistance protein 1 (MRP1), which is structurally similar to P-gp, is the product of the ABCC1 gene and can export anthracenedione, anthracycline, epipodophyllotoxin, vinca alkaloids, etc.
Novantrone(R) is a synthetic antineoplastic anthracenedione used intravenously as an anti-cancer agent.
Pixuvri is a novel anthracenedione that lacks the structural motifs that lead to the formation of reactive oxygen species or long-lived hydroxyl metabolites which are believed to be involved in cardiac damage.
titled "The novel anthracenedione, pixantrone, lacks redox activity and inhibits doxorubicinol formation in human myocardium; Insight to explain the cardiac safety of pixantrone in doxorubicin treated patients," is available at http://jpet.
Mitoxantrone is a synthetic antineoplastic anthracenedione initially approved for the treatment of acute myeloid leukaemia in 1987.
Novantrone is a synthetic anthracenedione that acts as a Topo II inhibitor and a DNA intercalator.