Effects of antalarmin
, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rate.
Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin
in the chronic mild stress model of depression in mice.
Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout.
The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats.
Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF 1 receptor antagonist antalarmin
and by CRF1 receptor knockout.
Social stress increases tumor development: Effects of antalarmin
a CRF type 1 receptor antagonist and nadolol a beta-adrenergic antagonist.
According to those who worked on the studies, the research community has begun to develop antalarmin
for use in humans.
The NIMH is performing its own toxicology studies in collaboration with other federal institutes on a CRH antagonist developed within NIMH called antalarmin
, he said.
switches off the stress circuit, said Dr.
Fewer embryos attached successfully to the uterus in rats receiving antalarmin
than in control rats.
The impact of the nonpeptide corticotrophin-releasing hormone antagonist antalarmin
on behavioral and endocrine responses to stress.
A host of animal studies show that antalarmin
selectively binds to CRH 1 receptors, thus blocking the binding of CRH.