Documented external abnormalities include: skull abnormality; ear abnormalities (including anotia
, micropinna, small or absent external auditory canals); eye abnormalities (including microphthalmia); facial dysmorphia; cleft palate.
The remnant of the damaged pinna serves as a guide to the maxillofacial prosthodontists in positioning a prosthetic ear, but for bilateral anotia
and microtia no such guide exists.
A case of isotretinoin embryopathy with bilateral anotia
and Taussig-Bing malformation.
2,3) Such anomalies include anotia
, microtia, cleft ears, polyotia, preauricular tags or sinuses, and absent or supernumerary cartilage bars--all of which exhibit severe deficiencies or significant aberrations of the major auricular landmarks.
Case 07 Bilateral anotia
Left diaphragmatic hernia, horse-shoe kidney, double ureters.
The human data now available appear in published and unpublished reports associating the drugs with an increased risk of spontaneous abortions and serious congenital malformations, including bilateral microtia or anotia
, sometimes with atresia of the external auditory canals; oral clefts; and other major structural malformations, according to the FDA.
Repair of microtia or anotia
(small or no ear formation) is typically treated when the child grows older for best results.