GRHL2 is a transcription factor playing roles in development, regulation of epithelial mesenchymal transition (EMT), and restoring the sensitivity to anoikis
Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis
Grape seed extract induces anoikis
and caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: possible role of ataxia telangiectasia mutated-p53 activation, Mol Cancer Ther.
Schafer, Coleman Assistant Professor of Cancer Biology at Notre Dame, metastasis, the spread of cancer from one organ to other parts of the body, relies on cancer cells ability to evade a cell death process called anoikis
She describes the dynamics of the prostate gland; apoptosis pathways signaling execution of cancer cells; androgen receptor-mediated apoptosis; new concepts related to the development of resistance by androgen-independent tumors, in terms of the contribution of anoikis
and cross-talk of androgens with key growth factor signaling pathways; epithelial-mesenchymal transition in metastasis; the exploitation of the apoptotic and angiogenic synergism towards complete eradication of tumors; novel molecular therapeutics; apoptotic-based molecular markers of therapeutic response; the role of apoptosis in cancer prevention; and the drug development challenge based on analysis of data from clinical trials.
Diindolylmethane-mediated Gli1 protein suppression induces anoikis
in ovarian cancer cells in vitro and blocks tumor formation ability in vivo.
Malignant pleural mesothelioma cells resist anoikis
as quiescent pluricellular aggregates.
Exogenous expression of [beta]-catenin regulates contact inhibition, anchorage-independent growth, anoikis
, and radiation-induced cell cycle arrest.
This phenomenon, referred to as anoikis
(homelessness), was assumed to prevent cells that have lost contact with their original surroundings, from establishing themselves at inappropriate locations.
CEACAM6 gene silencing impairs anoikis
resistance and in vivo metastatic ability of pancreatic adenocarcinoma cells.
Metformin inhibits growth and decreases resistance to anoikis
in medullary thyroid cancer cells.
is the process by which cells are triggered to die when separated from their surrounding matrix and neighbouring cells.