An immune response manifested by the common occurrence of annexins I and II autoantibodies and high circulating levels of IL-6 in lung cancer.
The treatment with eurycomanone reduced the abundance expression of the lung cancer markers, heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1, p53 tumor suppressor protein and other cancer-associated genes including prohibitin (PHB), annexin 1 (ANX1) and endoplasmic reticulum protein 28 (ERp28) but not the house keeping genes.
1]-antitrypsin, 2%); annexins, 1%; and complement factors, 1%.
Other identified proteins, such as annexins A1, A2, A3, and A5, have proved to be inhibitors of phospholipase A2.
Dysferlin interacts with Annexins A1 and A2 and Mediates Sarcolemmal Wound- healing.
In case of spots which displayed reduced expression levels, structural proteins like Septin-2, cofilin-1 and macrophage capping protein; proteins involved in cellular processes like Annexin 1, Annexin 4, Annexin 5 and proteins involved in metabolism like phosphoglycerate mutase, triosephosphate isomerase, peptidyl-prolyl cis-trans isomerase were identified (Figure 5; Table 2).
Possible use of Annexins as vaccines for lung and oesophagus cancers
confirmed the central role that Annexins 1 and 2 play in tumour development,
belong to a family of the calcium-dependent phospholipid binding proteins and are substrates of receptor tyrosine kinases.
A1 is a member of the annexins
Cellular processes : Annexins
are the family of calcium-dependent phospholipid binding proteins.
Circulating Gc-globulin colocalizes with both CD44 and annexin
A2 receptors on the cell surface and may use both pathways to enhance C5a-mediated chemotaxis (33).