annexin 5

(redirected from annexin V)

annexin 5

A member of a highly conserved protein family that bind acidic phospholipids in a calcium-dependent manner and help flag cells destined for apoptotic death by phagocytes. Annexin 5 has a high affinity for phosphatidylserine and is transported from the inner to the outer face of the plasma membrane, where cells undergo death by apoptosis or cell necrosis. It has known anticoagulant properties and, like lactadherin, has high-affinity, PS-dependent membrane-binding-like factor VIII and factor V.
References in periodicals archive ?
Annexin V, propidium iodide and Hoechst staining: For Annexin V, staining suspensions of cumulus cells from individual oocytes were incubated with 1 [micro]l of Annexin V (2.
METHODS: We measured urinary levels of four PAH metabolites and assessed semen quality, sperm apoptotic markers with Annexin V assay, and sperm DNA damage with comet assay in 232 men from Chongqing, China.
VisEn's Vice President of Applied Biology, said, "We developed an Annexin red imaging agent, Annexin-Vivo 750, which targets Annexin V, a well-characterized biomarker for apoptosis.
For detecting early and late apoptosis in leukocytes, complex methods are required, such as flow cytometric measurements of annexin V expression in combination with 7-amino-actinomycin D (7AAD) nuclei staining (6).
Human neutrophils lose their surface Fc gamma RIII and acquire Annexin V binding sites during apoptosis in vitro.
Its lead radiopharmaceutical product candidate is Hynic-Annexin V which is based upon the Apomate(TM) technology platform and is a kit for the preparation of Technetium Tc-99m labeled Annexin V.
Apoptosis induction by the expression of capsid was also determined by annexin V staining procedure followed by fluorescence-activated cell sorter analysis.
Annexin V is a naturally occurring human protein which has been shown to bind to cells undergoing apoptosis, a fundamental process of programmed cell death which is central to many biological events.
Nasdaq:NASI) and Theseus Imaging Corporation have announced that Theseus has initiated a clinical trial of its Apomate(TM) Kit for the preparation of Technetium Tc-99m recombinant human Annexin V for imaging apoptosis in tumors before and after anti-cancer treatment.
Annexin V moves calcium ions across membranes, but its overall role in animals is not known.
We are extremely pleased to be working with VisEn, a clear leader in the field of in vivo fluorescent imaging and the perfect partner in enabling the new in vivo imaging applications using our Annexin V technology platforms," said Peter Moonen, CEO of MosaMedix.
Our strategy was to enrich for all PS-exposing cells, using the Annexin V Microbead Kit (Miltenyi Biotec) and then to examine for the presence of NRBCs in the positively enriched fraction.