annexin


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annexin

A generic term for a large (160 +) family of calcium- and phospholipid-binding proteins and phospholipase A2- and blood coagulation inhibitors, which interact with acidic membrane phospholipids in cell membranes.

annexin

One of a family of over 20 proteins first described in 1990, that include vascular anticoagulant proteins, placental proteins, placental anticoagulant proteins, lipocortins and endonexins. Annexins have similar structures, usually with four domains of 70 amino acids, and all are capable of binding calcium and phospholipids. They are present in a wide variety of cell types. Annexin II acts to bind plasminogen and TISSUE PLASMINOGEN ACTIVATOR to the endothelial cell surface. Annexin V forms an antithrombotic shield around procoagulant phospholipids.
References in periodicals archive ?
Apoptosis caused by cisplatin treatment was analyzed quantitatively by a FITC Annexin V Apoptosis Detection kit II (BD Biosciences, Franklin Lakes, NJ, USA) (Chang et al.
Circulating Gc-globulin colocalizes with both CD44 and annexin A2 receptors on the cell surface and may use both pathways to enhance C5a-mediated chemotaxis (33).
The gene functions of this cluster are diverse containing among others, Ly6d (lymphocyte antigen 6 complex), a lymphocytic marker; Cstb (cathespin), an intracellular thiol inhibitor; Nqo1 (DT-diaphorase) a two-electron quinone oxidoreductase whose expression is often associated with redox stress; and another member of the annexin family, others of which are in the cluster shown in Figure 3A; and Krt8 (Keratin 8), commonly associated with Mallory body formation.
Annexin staining confirmed a dose-dependent increase in apoptosis caused by exposure to GRN163L.
Moreover, SC increased the number of annexin V-positive apoptotic bodies and phosphorylated JNK and p38 in AGS cells.
VisEn's Vice President of Applied Biology, said, "We developed an Annexin red imaging agent, Annexin-Vivo 750, which targets Annexin V, a well-characterized biomarker for apoptosis.
For detecting early and late apoptosis in leukocytes, complex methods are required, such as flow cytometric measurements of annexin V expression in combination with 7-amino-actinomycin D (7AAD) nuclei staining (6).
Hcy in plasma is mainly bound to albumin, but interactions with ceruloplasmin, fibrin, annexin II, and transthyretin have been also reported (1-4).
The Company intends to temporarily maintain the clinical trial data, intellectual property developed during the program and the existing GMP Annexin material until October 31, 2004, in an effort to assist companies that may be interested in purchasing the assets of the program.