ankyrin repeat


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ankyrin repeat

A short repetitive sequence of amino acids consisting of a beta strand followed by two alpha helices and a beta strand. The beta strands on adjacent ankyrin repeats combine to form a short antiparallel beta sheet. Ankyrin repeats were first identified in ankyrin, which tethers different proteins (e.g., nuclear and cytoplasmic proteins), helping regulate gene expression and embryonic development.
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receptors, kinases and angiogenesis pathways) - Monoclonal antibodies, mAb fragments, DARPins (designed ankyrin repeat proteins) and visual cycle modulators.
In a one-year re-integration phase I will perform follow-up mechanistic structural studies in the Olga Mayans lab (University of Liverpool) to determine the structural basis how the CARP (cardiac ankyrin repeat protein)-titin signaling axis mediates cardiomyocyte protection, and in the Labeit lab (University of Heidelberg, Medical Faculty Mannheim) how to perturb activity of this complex by small molecules.
receptors, kinases and angiogenesis pathways) -- Monoclonal antibodies, mAb fragments, DARPins (designed ankyrin repeat proteins) and visual cycle modulators.
Source:RefSeq mRNA;Acc :NM_001109946] ENSSSCG00000005 607 RALGPS 1 Ral GEF with PH domain and SH3 binding motif 1 [Source:HGNC Symbol;Acc:16851] ENSSSCG00000005 679 ASB6 Sus scrofa ankyrin repeat and SOCS box containing 6 (ASB6), mRNA.
Conformation-dependent recognition of HIV gp120 by designed ankyrin repeat proteins provides access to novel HIV entry inhibitors," Journal of Virology 87(10): 5868-5881.
Designed Ankyrin Repeat Proteins (DARPins): From research to therapy
Monoclonal antibodies (mAbs), mAb fragments, DARPins (designed ankyrin repeat proteins), and visual cycle modulators
today announced plans to begin a Phase 1 clinical trial for a small molecule antagonist of the human Transient Receptor Potential Ankyrin repeat 1 (TRPA1) ion channel discovered in a collaboration between Cubist and Hydra.
ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene.
receptors, kinases and angiogenesis) -- Monoclonal antibodies (mAbs), mAb fragments, DARPins (designed ankyrin repeat proteins), and visual cycle modulators -- Anti-inflammatory mechanisms (inc.
The intracellular domain contains six ankyrin repeats, the final motif found in Notch.
The center has discovered that B cell scaffold protein with ankyrin repeats (BANK), a kind of adapter molecule, inhibits the immune response of the B cell.