Typical I[kappa]B proteins are composed of an N-terminal regulatory domain, a central ankyrin
(ANK) repeat region (ARR), and a region of a sequence rich in proline (P), glutamic acid (E), serine (S), and threonine (T) residues (known as PEST) (Traenckner et al.
Vital erythroid aggregation occurs in spectrin and ankyrin
receptors on the surface of red blood cells.
The intracellular domain contains six ankyrin
repeats, the final motif found in Notch.
High frequency of de novo mutations in ankyrin
gene (ANK1) in children with hereditary spherocytosis.
1 his tone deacetylase complex; transcription corepressor activity corepressor activity 215378_at Ankyrin
repeat and KH domain 5q31.
Last, the low-density GWAS recently published by Kozyrev and colleagues (45) suggest that functional variants in the B-cell gene BANK1 (B-cell scaffold protein with ankyrin
repeats) are associated with SLE.
A gene called Ankyrin
3 (ANK3) showed the strongest association with bipolar disorder.
Vital erythroid aggregation takes place with the spectrin ankyrin
and actin proteins on the membrane of red blood cells.
The new mechanism involves a protein called ankyrin
and appears to regulate specialized pancreatic cells and insulin secretion
CD4-Specific designed ankyrin
repeat proteins are novel potent HIV entry inhibitors with unique characteristics," PLoS ONE 4(7): e1000109.
50] There is, however, a growing understanding of the connection between neurons and proteins classically associated with the red blood cell cytoskeleton: ankyrin
,[56,57] spectrin,[57-60] band 4.
today announced plans to begin a Phase 1 clinical trial for a small molecule antagonist of the human Transient Receptor Potential Ankyrin
repeat 1 (TRPA1) ion channel discovered in a collaboration between Cubist and Hydra.