ankyrin


Also found in: Encyclopedia, Wikipedia.

an·ky·rin

(ang'ki-rin),
An erythrocyte membranal protein that binds spectrin. A deficiency in ankyrin may lead to a type of hereditary spherocytosis.
See also: nexins.
Synonym(s): anchorin, syndein
[G. ankyra, anchor, + -in]

ankyrin

/an·ky·rin/ (ang´kĭ-rin) a membrane protein of erythrocytes and brain that anchors spectrin to the plasma membrane at the sites of ion channels.

ankyrin

Any of a family of proteins which mediate the binding of integral membrane proteins to the cytoskeleton, e.g., spectrin to the erythrocyte’s anion exchange (band-III) protein.

ankyrin

(ang′kĭ-rin)
A structural protein in red blood cells that binds cell membrane transport molecules to spectrin.
References in periodicals archive ?
Typical I[kappa]B proteins are composed of an N-terminal regulatory domain, a central ankyrin (ANK) repeat region (ARR), and a region of a sequence rich in proline (P), glutamic acid (E), serine (S), and threonine (T) residues (known as PEST) (Traenckner et al.
The intracellular domain contains six ankyrin repeats, the final motif found in Notch.
High frequency of de novo mutations in ankyrin gene (ANK1) in children with hereditary spherocytosis.
1 his tone deacetylase complex; transcription corepressor activity corepressor activity 215378_at Ankyrin repeat and KH domain 5q31.
Last, the low-density GWAS recently published by Kozyrev and colleagues (45) suggest that functional variants in the B-cell gene BANK1 (B-cell scaffold protein with ankyrin repeats) are associated with SLE.
Vital erythroid aggregation takes place with the spectrin ankyrin and actin proteins on the membrane of red blood cells.
The new mechanism involves a protein called ankyrin and appears to regulate specialized pancreatic cells and insulin secretion
CD4-Specific designed ankyrin repeat proteins are novel potent HIV entry inhibitors with unique characteristics," PLoS ONE 4(7): e1000109.
50] There is, however, a growing understanding of the connection between neurons and proteins classically associated with the red blood cell cytoskeleton: ankyrin,[56,57] spectrin,[57-60] band 4.
today announced plans to begin a Phase 1 clinical trial for a small molecule antagonist of the human Transient Receptor Potential Ankyrin repeat 1 (TRPA1) ion channel discovered in a collaboration between Cubist and Hydra.