animal model


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Related to animal model: Mouse model, Model organism

an·i·mal mod·el

study in a population of laboratory animals that uses conditions in animals analogous to conditions of humans to simulate processes comparable with those that occur in human populations.

animal model

An animal that is an accidental or deliberate (though selective inbreeding) model of a human disease. Such models are experimental living systems that are used to study disease mechanisms and provide insight into possible therapies.

Animal models
• AIDS—SAIDS in macaque monkeys. 
• ALL—Immune deficient SCID mice. 
• Atherosclerosis—Watanabe rabbits. 
• Ceroid lipofuscinosis—Border collies.
• Charcot-Marie-Tooth disease type 1A—Pmp-22 mutant trembler-J mice.
• Congenital hyperbilirubinemia—Gunn rat enzymopathy.
• Congenital malignancy—Embryonal nephroma—pigs; hepatoblastoma—sheep; melanoma—darkly pigmented animals. 
• Crohn’s disease—Paratuberculosis/Johne’s disease, which affects dairy ruminants by Mycobacterium johnei.
• Cryptorchidism—dogs (castration).
• Cystinuria type I—Newfoundland dogs; Pebbles, a transgenic mouse model.
• Demyelination—Shiverer mouse.
• Diabetes insipidus—Brattleboro rats.
• Distichia—Cocker spaniels, dachshunds, bulldogs, Yorkshire terriers, poodles.
• End-organ resistance to normal hormones—Sebright bantam rooster.
• Endocardial fibrosis—Turkeys.
• Familial hypercholesterolaemia—Watanabe rabbits.
• Fibrosing alveolitis/Hamman-Rich disease—Bovine pulmonary disease. 
• GH-resistant dwarfism—Mini-mouse.
• Inherited giant platelet disorders—King Charles Spaniel dogs (Cavaliers).
• Kinky hair disease—Copper deficiency in sheep.
• Klinefelter syndrome—X-linked testicular feminisation in mice.
• Lymphocytic thyroiditis—Beagles, obese chickens, buffalo rats, primates.
• Lymphoma—Lymphosarcoma in dogs. 
• Malignant histiocytosis—Bernese Mountain dogs.
• Melanoma, spontaneously regressing—Sinclair swine.
• Mixed tumour (benign breast tumour)—Dogs.
• Muscular hypertrophy—Belgian blue cows.
• Myotonia congenita—Fainting goats.
• Neurolymphomatosis—Marek’s disease, induced by an oncogenic herpesvirus.
• Neuroplasticity—Aplysia, a marine mollusc.
• Osteopetrosis—Gray lethal mouse.
• Pacinian neurofibroma—Peking duck.
• Protothecosis—Collie dogs.
• Rheumatoid arthritis—Erysipelothrix-induced arthritis.
• Sleep apnea (obstructive)—English bulldog.
• Spermatocytic seminoma—old men and old dogs.
• Systemic lupus—NZB/NZW mice.
• Waardenburg syndrome—ferrets.

an·i·mal model

(an'i-măl mod'ĕl)
Study in a population of laboratory animals that uses conditions of animals analogous to conditions of humans to simulate processes comparable with those that occur in human populations.

model

a simulation, a copy, occurring naturally or manufactured. Models used in statistical and epidemiological studies may be deterministic, stochastic or random.

model 1
the fixed version of the linear additive model used in linear regression analysis.
model 2
the random version of the linear additive model used in linear regression analysis.
animal model
any condition in an animal that has enough similarities to a condition in humans that studies of the animal disease are will assist in understanding the human disorder.
causal model
a model used to determine the part played by multiple factors in the cause or causes of disease; a path model in which the variables are arranged temporally.
descriptive model
consist largely of diagrams and maps or charts designed to describe a real-world system.
deterministic model
see epidemiological model (below).
epidemiological model
a mathematical model, which may be a computer simulation model, of a disease for the purpose of studying the behavior of the disease in a variable animal population under variable conditions of climate, density of population, mix of population, and so on. It may be an analytical model, an economic decision making model, an explanatory model or a predictive model. It may also be a causal model, which allows the operator to vary the determinants of prevalence and observe the respective outcomes. It may permit only the use of fixed numbers so that it will always return the same answer to the same question, in which case it is a deterministic model, or it may introduce the element of chance into the selection of outcomes, in which case it is a stochastic model.
Specific computer simulation models have been prepared for the study of rinderpest, the costs of mastitis control, the cost-benefits of foot-and-mouth disease control, and the costs of mortality in dairy calves. For example see reed-frost model.
linear programming model
a statistical model of a dependent variable, e.g. Y, as a linear combination of other variables, e.g. X. The model is based on a series of linear equations with a linear equation, called the objective function, as the desired end. Such an end could, in the determination of lowest cost rations, be the total cost of each ration.
mathematical model
a representation of a system, process or relationship in a mathematical form; see also mathematical modeling.
physical model
e.g. a model of a molecule utilizing colored balls connected by rigid wires.
probabilistic model
includes basic concepts of probability theory and may be deterministic or stochastic.
Reed-Frost model
a deterministic probability model of a theoretical epidemic.
stochastic model
see epidemiological model.
symbolic model
mathematical symbols used to describe the status of variables at a given time and to define the manner in which they change and interact.
References in periodicals archive ?
For more information on the new animal model, go to (http://www.
Chapter 6, which focuses on the mouse, concludes with a discussion of the issue of developing more predictive animal models of drug efficacy, specifically more predictive mammalian models.
Three other Society-funded projects are also looking at animal models of MS.
Animal models of depression that encompass deficiencies in 5HT synaptic function display a uniform set of behavioral parallels: locomotor hyperactivity and increased open-arm time in the elevated plus maze, anhedonia in the chocolate milk consumption test, and cognitive impairment; all of these resolve with therapies that restore 5HT function to normal (Cairncross 1984; Cryan et al.
Currently, the pharmaceutical industry is utilizing a variety of animal model systems ranging from worms (C.
But if the animal model doesn't replicate the human disease, researchers may still find it useful.
The animal model is the first animal model of absence epilepsy to incorporate a genetic change identified in human patients and to demonstrate the same EEG brain patterns of human patients.
235) is a validated animal model of anxiety and has provided substantial insight into the neuropharmacology of anxiety and the development of anti-anxiety drugs, but no one would argue that a rat on the plus maze is "anxious.
Yet even with an animal model, researchers say it may take many years to find a promising drug that works in humans.
Preventing cancer from recurring in animal models is an important benchmark in developing new cancer therapeutics and toward prolonging life.
Examples of research areas appropriate to this PA include, but are not limited to, projects to 1) expand the number of nonhuman animal model systems in which embryonic stem cells are available; 2) identify, isolate, culture, and characterize multipotent stem cell populations derived from nonhuman embryonic stem cells; 3) identify, isolate, culture, and characterize multipotent stem cells from postfetal tissue types; 4) generate and use panels of markers for stem cell attributes common across species for use in characterization and isolation of stem cells in a range of animal species or tissues; and 5) create universal methods of culture to maintain the undifferentiated state of embryonic or other characterized multipotential stem cells across nonhuman animal species.
The animal model development will include determining the time necessary for tendon healing and the development of methods to accurately assess the functional deficit resulting from peritendinous adhesion formation.