Of the 10 fetuses with follow-up data, the option of termination was offered in 6 cases of anhydramnios
, including 3 cases with signs of infravesical obstruction (a possible posterior urethral valve (PUV) and poor prognostic factors and 3 cases with unilateral hydronephrosis and increased echogenicity in the contralateral kidney.
Terminated cases, because of associated severe / lethal extra-cardiac pathologies (Group A) Pathological classification n = 39 Clinical diagnosis (n) Chromosomal pathologies 23 Trisomy 21 (n=13), trisomy 18 (n=8), trisomy 13 (n=2) Genitourinary pathologies 6 Bilateral renal agenesis (n=2), multicystic dysplastic kidneys associated with oligo- / anhydramnios
(n=4) Central nervous system 7 Anencephaly (n=1), pathologies holoprosencephaly (n=2), hemivertebra (n=l), vermis agenesis (n=1), neural tube defect (n=2) Other 3 Severe generalized hydrops / septated cystic hygroma (n=3) Table 3.
A decline in blood volume for the donor twin leads to decreased urine output to the extent that bladder filling virtually ceases and oligohydramnios may progress to anhydramnios
Efficacy of amnioinfusion in anhydramnios
at term before induction of labor and newborn outcome.
Although no congenital malformations were observed, fetal renal toxicity, as evidenced by oligohydramnios or anhydramnios
, was observed in three cases.