angiotensin-converting enzyme

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 (ACE) [an″je-o-ten´sin]
a vasoconstrictive substance formed in the blood when renin is released from the juxtaglomerular apparatus in the kidney. The enzymatic action of renin acts on angiotensinogen to form the decapeptide angiotensin I, which is relatively inactive. It in turn is acted upon by peptidases (converting enzymes), chiefly in the lungs, to form the octapeptide angiotensin II, a powerful vasopressor and a stimulator of aldosterone secretion by the adrenal cortex. By its vasopressor action, it raises blood pressure and diminishes fluid loss in the kidney by restricting blood flow. Angiotensin II is hydrolyzed in various tissues to form heptapeptide angiotensin III, which has less vasopressor activity but more effect on the adrenal cortex.
angiotensin-converting enzyme (ACE) an enzyme of the hydrolase class that catalyzes cleavage of a dipeptide from the C-terminal end of angiotensin I to form activated angiotensin II; called also peptidyl-dipeptidase A.
angiotensin-converting enzyme inhibitors competitive inhibitors of angiotensin-converting enzyme, which converts angiotensin I to angiotensin II and inactivates bradykinin. ACE inhibitors, such as captopril, are antagonists of the renin-angiotensin-aldosterone system and potentiators of the kinin system and are used for treatment of hypertension, usually in conjunction with a diuretic. They are also used as vasodilators in the treatment of congestive heart failure.

an·gi·o·ten·sin-con·vert·ing en·zyme (ACE),

A zinc-containing hydrolase cleaving C-terminal dipeptides from a variety of substrates, including angiotensin I, which is converted to angiotensin II and histidylleucine (an important step in the metabolism of certain vasopressor agents). Drugs that inhibit it are used to treat hypertension and congestive heart failure.

angiotensin-converting enzyme

/an·gio·ten·sin-con·vert·ing en·zyme/ (-ten´sin kon-vert´ing en´zīm) see peptidyl-dipeptidase A.

angiotensin-converting enzyme (ACE)

a glycoprotein (dipeptidyl carboxypeptidase) that catalyzes the conversion of angiotensin I to angiotensin II by splitting two terminal amino acids. ACE-inhibiting agents are used for controlling hypertension and for protecting the kidneys in diabetes mellitus.

angiotensin-converting enzyme

Peptidyl-dipeptidase A is the name recommended by the IUBMB for this enzyme (EC, though it is more popularly known as angiotensin I-converting enzyme (ACE).

angiotensin-converting enzyme

A key enzyme in the RAA system, which converts the inactive decapeptide angiotensin I to the octapeptide, angiotensin II, a potent vasoconstrictor that also stimulates aldosterone secretion; ACE is also involved in metabolizing bradykinin Ref range 18–67 U/L, > age 20; those < 20 have higher levels; ACE is ↑ in sarcoidosis, Gaucher disease, leprosy, histoplasmosis, cirrhosis, asbestosis, berylliosis, DM, Hodgkin's disease, hyperthyroidism, amyloidosis, PBC, idiopathic pulmonary fibrosis, PE, scleroderma, silicosis, TB; ACE ↓ in response to prednisone therapy for sarcoidosis. See Renin/angiotensin/aldosterone system.

an·gi·o·ten·sin-con·vert·ing en·zyme

(ACE) (an'jē-ō-ten'sin-kŏn-vĕrt'ing en'zīm)
A hydrolase responsible for the conversion of angiotensin I to the vasoactive angiotensin II by removal of a dipeptide (histidylleucine) from angiotensin I. Drugs that inhibit ACE are used to treat hypertension and congestive heart failure.

angiotensin-converting enzyme

The (ACE) enzyme that converts angiotensin I to the active form angiotensin II. The gene for this enzyme has two alleles, the I allele and the D allele. Research has shown that the I allele is associated with significantly better physical performance, endurance and response to physical training than the D allele. The difference is especially marked if the I allele is present at both loci and compared with people with the D allele at both loci.

angiotensin-converting enzyme (anˑ·jē·ō·ten·sin kon·verˑ·ting enˑ·zīm),

n glycoprotein that converts angiotensin I to angiotensin II by dividing two terminal amino acids.
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References in periodicals archive ?
A new method for the in vitro screening of inhibitors of angiotensin-converting enzyme (ACE), using the chromophore- and fluorophore-labelled substrate dansyltriglycine.
Partial escape of angiotensin-converting enzyme (ACE) inhibition during prolonged ACE inhibitor treatment: Does it exist and does it affect the antihypertensive response?
Serum angiotensin-converting enzyme in healthy and sarcoidotic children: comparison with the reference interval for adults.
These results show that simultaneous inhibition of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE) with a VPI may provide greater cardiovascular benefits than previously seen with ACE-inhibition alone.
After noting that angiotensin-converting enzyme inhibitors (ACEIs) boosted muscle strength in patients who took the drugs for both congestive heart failure (CHF) and hypertension, Dr.
Angiotensin-converting enzyme DDgenotype in patients with ischaemic or idiopathic dilated cardiomyopathy.
Horovitz was instrumental in the initial development and commercialization of angiotensin-converting enzyme inhibitors (Capoten(R)), for which he was recognized with an American Heart Association Discovery Award.
Lisinopril inhibits angiotensin-converting enzyme (ACE) in human subjects and animals.
The guidelines, released June 28, by the Agency for Health Care Policy and Research (AHCPR), call for major changes in patient care, including the use of angiotensin-converting enzyme (ACE) inhibitors and vasodilator drugs.
Other Concomitant Therapy: Although specific interaction studies were not performed, PROSCAR was concomitantly used in clinical studies with a-blockers, angiotensin-converting enzyme (ACE) inhibitors, analgesics, anti-convulsants, beta-adrenergic blocking agents, diuretics, calcium channel blockers, cardiac nitrates, HMG-CoA reductase inhibitors, nonsteroidal anti-inflammatory drugs (NSAIDs), benzodiazepines, H2 antagonists and quinolone antiinfectives without evidence of clinically significant adverse interactions.
AdvancePCS is working with 11 manufacturers to offer discounts on 21 different drugs, including the nasal antihistamine Astelin, two hormone replacement therapy products, several angiotensin-converting enzyme inhibitors, and 10 oral contraceptives.
ATLANTA, March 14 /PRNewswire/ -- QUIET -- Quinapril Ischemic Event Trial -- a double-blind, placebo-controlled trial, is the first prospective study designed to assess the effects of angiotensin-converting enzyme (ACE) inhibition, using the ACE inhibitor quinapril (Accupril(R), Parke-Davis), on reducing coronary ischemia-related events and slowing progression of coronary artery disease in patients who traditionally would be considered at low risk for ischemia-related adverse outcomes.

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