There is a body of evidence suggesting that the renin-angiotensin system (RAS) may play a role in the pathophysiology of AF and that suppression of this system with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers
(ARBs) may prevent AF (3-10).
Figure 16: Angiotensin receptor blocker
US market share ($), 2007 87
Vascular and cardiac benefits of angiotensin receptor blockers
In contrast, ACE inhibitors and angiotensin receptor blockers
disrupt feedback inhibition of renin release from the kidney, and diuretics affect plasma renin activity through volume depletion.
AMEX:MCU) (TSX:MPH), a cardiovascular drug discovery and development company, is pleased to announce the initiation of the development program for a drug combining MC-1 and an Angiotensin Receptor Blocker
(ARB), one of the world's ten largest pharmaceutical drug classes by revenue.
4) An Angiotensin receptor blocker
(ARB) is a medication that blocks the action of angiotensin II, permitting the blood vessels to relax and dilate, which lowers the blood pressure.
The approval of the angiotensin receptor blocker
(ARB)--to reduce cardiovascular death and heart failure hospitalizations in patients with heart failure (NYHA II-IV and an ejection fraction of 40% or less)--now includes this statement: "Atacand also has an added effect on these outcomes when used with an ACE inhibitor.
announced today that they have signed a contract for a co-promotion agreement in the United States for Daiichi Sankyo's AZOR(TM), a fixed combination of two antihypertensives, the calcium channel blocker, amlodipine and the angiotensin receptor blocker
, olmesartan medoxomil.
Overall, 79% of the participants in Advancent SM were being treated with a [beta]-blocker, whereas 82% were on an ACE inhibitor or angiotensin receptor blocker
Forest Laboratories' growing line of products includes: Lexapro(R) an SSRI antidepressant indicated for the initial and maintenance treatment of major depressive disorder and Generalized Anxiety Disorder; Celexa(R), an antidepressant; Namenda(TM), an N-methyl D-aspartate (NMDA) receptor antagonist indicated for the treatment of moderate to severe Alzheimer's disease; Tiazac(R), a once-daily diltiazem, indicated for the treatment of angina and hypertension; Benicar(R)*, an angiotensin receptor blocker
indicated for the treatment of hypertension; Benicar HCT, an angiotensin receptor blocker
and diuretic combination product indicated for the second- line treatment of hypertension; and Aerobid(R), an inhaled steroid indicated for the treatment of asthma.
MUNICH -- The angiotensin receptor blocker
telmisartan offered renoprotection comparable to that of an ACE inhibitor in the first long-term, head-to-head study of the two drug classes in patients with hypertensive type 2 diabetic early nephropathy, Anthony H.
announced today that they have signed a Letter of Intent to enter into a definitive co-promotion agreement in the United States for AZOR(TM), a fixed-dose combination of two antihypertensives, the calcium channel blocker amlodipine besylate and the angiotensin receptor blocker