Combination therapy with an ACE inhibitor and an angiotensin receptor blocker
for diabetic nephropathy: a meta-analysis.
The combination of a low-dose diuretic with agents that block the effects of the renin-angiotensin system (RAS), such as angiotensin receptor blockers
, has been found in numerous clinical trials to be highly effective for lowering blood pressure in patients with uncomplicated as well as high-risk hypertension, with a comparable favorable side effect profile compared with monotherapy.
Entresto is usually administered in conjunction with other heart failure therapies, in place of an ACE inhibitor or other angiotensin receptor blocker
The drug is indicated for treating high blood pressure in patients not adequately controlled on aliskiren or angiotensin receptor blocker
(ARB) monotherapy and as an initial therapy in patients likely to need multiple drugs to achieve blood pressure goals.
The measures identified for heart failure include discharge instructions, left ventricular function assessment as measured by an echocardiogram, discharge prescription for an angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker
for left ventricular systolic dysfunction, and smoking cessation advice/counseling.
The angiotensin-converting enzyme inhibitor (ACEI) ramipril and the angiotensin receptor blocker
(ARB) telmisartan are equally effective for secondary cardiovascular prevention.
Norvasc, a calcium channel blocker, relaxes blood vessels, while olmesartan uses an angiotensin receptor blocker
to ease blood-vessel constriction.
An angiotensin receptor blocker
(ARB) discovered by Takeda, TAK-491 helps lower blood pressure by suppressing the action of vasopressor hormone Angiotensin II.
Novartis AG, Basel, Switzerland, announced the US Food and Drug Administration (FDA) has approved Diovan, the most prescribed angiotensin receptor blocker
(ARB) worldwide, for a new indication to reduce cardiovascular death in patients with high risk (with left ventricular failure or left ventricular dysfunction) following a heart attack.
Table 12: US-approved angiotensin receptor blocker
indications, 2009 36
The company stated that Entresto is usually administered along with other heart failure therapies in place of an ACE inhibitor or other angiotensin receptor blocker
Effect of preoperative angiotensin converting enzyme inhibitor or angiotensin receptor blocker
use on the frequency of atrial fibrillation after cardiac surgery: a cohort study from the atrial fibrillation suppression trials II and III.