angiotensin receptor blocker


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angiotensin receptor blocker (ARB),

agent that binds with angiotensin receptors, thus preventing access of angiotensin II to the receptor and consequently reducing the vasoconstriction produced by this agonist; used in the treatment of hypertension.

angiotensin II receptor antagonist

Any of a family of agents (e.g., losartan and valsartan) that block the binding of angiotensin II (A-II) to their cognate cell receptors—AT1, AT2 and others. First-generation ARAs included the sartan family of agents, which only block AT1, interacting with the amino acids in the transmembrane domains to block the binding of A-II to AT1.

ARAs are an alternative to ACEI therapy in patients with CHF; unlike ACEIs, ARAs do not interfere with bradykinin and prostaglandin metabolism, interference of which has been linked to some of the adverse effects of ACEI therapy, particularly to cough and angioedema.

an·gi·o·ten·sin re·cep·tor block·er

(an'jē-ō-ten'sin rĕ-sep'tŏr blok'ĕr)
An agent (e.g., losartan) that binds with angiotensin receptors, thus preventing access of angiotensin II to the receptor and consequently reducing the vasoconstriction produced by this agonist; used in the treatment of hypertension.
References in periodicals archive ?
There is a body of evidence suggesting that the renin-angiotensin system (RAS) may play a role in the pathophysiology of AF and that suppression of this system with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) may prevent AF (3-10).
In contrast, ACE inhibitors and angiotensin receptor blockers disrupt feedback inhibition of renin release from the kidney, and diuretics affect plasma renin activity through volume depletion.
AMEX:MCU) (TSX:MPH), a cardiovascular drug discovery and development company, is pleased to announce the initiation of the development program for a drug combining MC-1 and an Angiotensin Receptor Blocker (ARB), one of the world's ten largest pharmaceutical drug classes by revenue.
4) An Angiotensin receptor blocker (ARB) is a medication that blocks the action of angiotensin II, permitting the blood vessels to relax and dilate, which lowers the blood pressure.
The approval of the angiotensin receptor blocker (ARB)--to reduce cardiovascular death and heart failure hospitalizations in patients with heart failure (NYHA II-IV and an ejection fraction of 40% or less)--now includes this statement: "Atacand also has an added effect on these outcomes when used with an ACE inhibitor.
announced today that they have signed a contract for a co-promotion agreement in the United States for Daiichi Sankyo's AZOR(TM), a fixed combination of two antihypertensives, the calcium channel blocker, amlodipine and the angiotensin receptor blocker, olmesartan medoxomil.
Overall, 79% of the participants in Advancent SM were being treated with a [beta]-blocker, whereas 82% were on an ACE inhibitor or angiotensin receptor blocker.
Forest Laboratories' growing line of products includes: Lexapro(R) an SSRI antidepressant indicated for the initial and maintenance treatment of major depressive disorder and Generalized Anxiety Disorder; Celexa(R), an antidepressant; Namenda(TM), an N-methyl D-aspartate (NMDA) receptor antagonist indicated for the treatment of moderate to severe Alzheimer's disease; Tiazac(R), a once-daily diltiazem, indicated for the treatment of angina and hypertension; Benicar(R)*, an angiotensin receptor blocker indicated for the treatment of hypertension; Benicar HCT, an angiotensin receptor blocker and diuretic combination product indicated for the second- line treatment of hypertension; and Aerobid(R), an inhaled steroid indicated for the treatment of asthma.
MUNICH -- The angiotensin receptor blocker telmisartan offered renoprotection comparable to that of an ACE inhibitor in the first long-term, head-to-head study of the two drug classes in patients with hypertensive type 2 diabetic early nephropathy, Anthony H.
announced today that they have signed a Letter of Intent to enter into a definitive co-promotion agreement in the United States for AZOR(TM), a fixed-dose combination of two antihypertensives, the calcium channel blocker amlodipine besylate and the angiotensin receptor blocker olmesartan medoxomil.

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