This trial compared ACE inhibitors with a different approach by using a drug, LCZ696 which is a combination of the Angiotensin receptor
blocker Valsartan and a Neprilysin Inhibitor Sacubitril.
The most up-to-date South African Hypertension Guideline  includes a consensus statement on the use of angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor
blockers (ARBs) for the management of hypertension, stating that the choice of therapy for either an ACEI or an ARB should be based on cost and tolerability.
In addition, a reduction in left atrial size at 36 weeks was observed in patients in the LCA696 group compared with those who received the angiotensin receptor
blocker, researchers led by Dr.
In the past five years, the number of prescriptions of ACE inhibitors and angiotensin receptor
blockers has risen to 13.
A preconceptional care program utilizing a multispecialty team approach is best for accomplishing the following beneficial goals: improved diet and lifestyle habits; treatment of hypoglycemia; reducing blood pressure to below 130/80 mm Hg; quitting smoking; switching patients from ACE inhibitors (pregnancy category D in the third trimester), angiotensin receptor
blockers (pregnancy category D in second and third trimester), and diuretics to drugs that are safer in pregnancy; and ensuring ophthalmologic consultation.
Table 11: Clinical efficacy of angiotensin receptor
II blockers (ARBs) are commonly used for the treatment of hypertension, heart failure, and diabetic neuropathy Because a number of large ARB trials have been completed since 2003, when "an unexpected finding" of significantly higher fatal cancers among patients taking the ARB candesartan was observed in a study assessing the efficacy of the drug in heart failure (Lancet 2003;362:759-66), Dr.
In clinical practice, it is often assumed that angiotensin receptor
blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) can be used interchangeably, except for the small proportion of patients who develop ACEI-associated cough.
An angiotensin receptor
blocker (ARB) for treating heart failure (New York Heart Association class II-IV) in people who cannot tolerate ACE inhibitors.
The angiotensin receptor
neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial.
The meta-analysis linking angiotensin receptor
blockers with an increased risk of incident cancer raises crucial drug safety questions.
Previous studies suggested that drugs used to treat high blood pressure, including ACE inhibitors and angiotensin receptor
blockers (ARBs), may help prevent the condition.