angiotensin II receptor antagonist


Also found in: Dictionary, Thesaurus, Financial, Encyclopedia, Wikipedia.
Related to angiotensin II receptor antagonist: ACE inhibitor, calcium channel blocker

angiotensin II receptor antagonist

Any of a family of agents (e.g., losartan and valsartan) that block the binding of angiotensin II (A-II) to their cognate cell receptors—AT1, AT2 and others. First-generation ARAs included the sartan family of agents, which only block AT1, interacting with the amino acids in the transmembrane domains to block the binding of A-II to AT1.

ARAs are an alternative to ACEI therapy in patients with CHF; unlike ACEIs, ARAs do not interfere with bradykinin and prostaglandin metabolism, interference of which has been linked to some of the adverse effects of ACEI therapy, particularly to cough and angioedema.

angiotensin II receptor antagonist

Pharmacology Any of a family of agents-eg losartan and valsartan, which block the binding of angiotensin II–A-II to its cognate cell membrane receptors–AT1, AT2, and others; 1st generation ARAs included the sartan family of agents, which only block AT1, interacting with the amino acids in the transmembrane domains, blocking the binding of A-II to AT1; an alternative to ACEI therapy for Pts with CHF; unlike ACEIs, ARAs do not interfere with bradykinin and prostaglandin metabolism, interference which has been linked to some of the adverse effects of ACEI therapy, particularly to cough and angioedema.
References in periodicals archive ?
Infants with histories of in utero exposure to an angiotensin II receptor antagonist should be closely observed for hypotension, oliguria, and hyperkalemia.
Therefore, serum lithium levels should be monitored carefully if lithium salts are to be co-administered with angiotensin II receptor antagonists.
elderly patients or patients who are volume-depleted, including those on diuretic therapy) who are being treated with non-steroidal anti-inflammatory drugs (NSAIDs) including those that selectively inhibit cyclooxygenase-2 inhibitors (COX-2 inhibitors), the co-administration of angiotensin II receptor antagonists including losartan, or ACE inhibitors may result in a further deterioration of renal function, including possible acute renal failure.
Drugs classes considered include Diuretics, Beta blockers, Alpha blockers, Adrenergic receptor agonists, Calcium channel blockers, ACE inhibitors, Angiotensin II receptor antagonists, Statins, Aldosterone antagonists or others (specified).
8 Percentage of patients who receive Angiotensin II Receptor Antagonists for the treatment of Hypertension
FIGURE 12 WORLDWIDE MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF ANGIOTENSIN II RECEPTOR ANTAGONISTS, 2009 (%) 72
TABLE 83 WORLDWIDE MARKET FOR ANGIOTENSIN II RECEPTOR ANTAGONISTS, THROUGH 2015 ($ MILLIONS) 124
FIGURE 37 WORLDWIDE MARKET FOR ANGIOTENSIN II RECEPTOR ANTAGONISTS, 2008-2015 ($ MILLIONS) 124
The report notes that although the number of commercial health plans placing step restrictions on angiotensin II receptor antagonists is relatively stable, a growing number of covered lives are subject to a step therapy restriction.

Full browser ?