angiotensin II


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an·gi·o·ten·sin II

(an'jē-ō-ten'sin),
A vasoactive octapeptide produced by the action of angiotensin-converting enzyme on angiotensin I; produces stimulation of vascular smooth muscle, promotes aldosterone production, and stimulates the sympathetic nervous system.

angiotensin II

An octapeptide derived from angiotensin I after angiotensin-converting enzyme acts on angiotensin I, cleaving the C-terminal dipeptide. Angiotensin II is a potent vasoconstrictor (4- to 8-fold more potent that norepinephrine) and has a very short (1–2 minutes) T1⁄2 in the circulation; it induces arteriolar constriction and increases systolic and diastolic blood pressure. Angiotensin II acts directly on the adrenal cortex, increasing aldosterone secretion, facilitating norepinephrine release by direct action on the post-ganglionic sympathetic neurons. It acts on the brain, increasing water intake, vasopressin and ACTH secretion.

an·gi·o·ten·sin II

(an'jē-ō-ten'sin)
A vasoactive octapeptide produced by the action of angiotensin-converting enzyme on angiotensin I; produces stimulation of vascular smooth muscle, promotes aldosterone production, and stimulates the sympathetic nervous system.

angiotensin II (anˈ·jē·ō·tenˑ·sin tōō),

n a powerful stimulant used to raise blood pressure by stimulating the release of aldosterone while concurrently causing vasoconstriction.
References in periodicals archive ?
The velocity of antihypertensive effects of seven angiotensin II receptor blockers determined by home blood pressure measurements J.
Regulation of megalin expression in cultured proximal tubule cells by angiotensin II type 1A receptor- and insulin-mediated signaling cross talk," Endocrinology, vol.
Saavedra, "Characterization of AT2 angiotensin II receptors in rat anterior cerebral arteries," American Journal of Physiology--Heart and Circulatory Physiology, vol.
The incubation of EPCs with angiotensin II decreased their proliferative capacity, measured as BrdU incorporation (decrease of luminescence approximately 50%), whereas pretreatment with AME counteracted that effect in a concentration-dependent manner (Fig.
Angiotensin ii as an inducer of atherosclerosis: Evidence from mouse studies.
Inhibition of RAS by converting enzyme inhibitors or angiotensin II receptor blockers captopril, enalapril, valsartan or telmisartan produced beneficial effects on the markers of metabolic syndrome and can reduce the frequency of metabolic syndrome in type 2 diabetic patients.
Higher ACE activity leads to increased Angiotensin II (AII) levels, which in turn promotes proliferation of mesangial cells and matrix.
When Edarbi blocks the angiotensin II receptor, blood vessels can stay relaxed and open, and blood pressure can be reduced.
All of these therapies--angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers, beta-adrenergic blocking agents (betablockers), aldosterone antagonists, hydralazine/ isosorbide dinitrate, implantable cardioverter defibrillators, and cardiac resynchronization therapy--are effective in treating heart failure, with the benefits outweighing the risks.
The review specifically looked at 31 randomized controlled trials that compared those taking with those not taking angiotensin II receptor blockers (ARBs) to determine the incidence of cancer.

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