angiotensin II


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an·gi·o·ten·sin II

(an'jē-ō-ten'sin),
A vasoactive octapeptide produced by the action of angiotensin-converting enzyme on angiotensin I; produces stimulation of vascular smooth muscle, promotes aldosterone production, and stimulates the sympathetic nervous system.

angiotensin II

An octapeptide derived from angiotensin I after angiotensin-converting enzyme acts on angiotensin I, cleaving the C-terminal dipeptide. Angiotensin II is a potent vasoconstrictor (4- to 8-fold more potent that norepinephrine) and has a very short (1–2 minutes) T1⁄2 in the circulation; it induces arteriolar constriction and increases systolic and diastolic blood pressure. Angiotensin II acts directly on the adrenal cortex, increasing aldosterone secretion, facilitating norepinephrine release by direct action on the post-ganglionic sympathetic neurons. It acts on the brain, increasing water intake, vasopressin and ACTH secretion.

an·gi·o·ten·sin II

(an'jē-ō-ten'sin)
A vasoactive octapeptide produced by the action of angiotensin-converting enzyme on angiotensin I; produces stimulation of vascular smooth muscle, promotes aldosterone production, and stimulates the sympathetic nervous system.

angiotensin II (anˈ·jē·ō·tenˑ·sin tōō),

n a powerful stimulant used to raise blood pressure by stimulating the release of aldosterone while concurrently causing vasoconstriction.
References in periodicals archive ?
For each experiment, the cells were cultivated in endothelial basal medium-2 (EBM-2) medium in presence or absence of human angiotensin II (Sigma) at a concentration 1.
1]R is one of the four G protein-coupled receptors that mediates intracellular signaling induced by angiotensin II (Touyz and Berry 2002).
By revealing that blood vessels in CADASIL patients over-react to the hormone angiotensin II the study offers insight into new approaches to prevent stroke and other brain disorders,' he said.
Most of the vascular effects of angiotensin II are mediated by way of its binding to the angiotensin II type I receptor, which is located primarily in the vascular smooth muscle cells, heart, kidney, and adrenal gland.
The ARBs' mechanism of action, selective inhibition of angiotensin II by competitive antagonism of the angiotensin II receptors, has been speculated to reduce adverse effects and possibly improve clinical efficacy.
The scientists working with Professor Platten showed in a mouse model that angiotensin II promotes inflammation in the brain and spinal cord.
Others discuss the molecular and physiological aspects of the angiotensin IV-ondulain regulated aminopeptidase interaction, its regulatory effects on cellular function, its biochemical and physiological actions and role in the treatment of cardiovascular diseases, its effects in renal fibrogenesis, the role of vitamin D in the modulation of the pancreatic rennin-angiotensin system, and pharmacotherapeutic effects of angiotensin II type 1 receptor blockers.
Among both groups, nearly half used high blood-pressure medications, such as calcium channel blockers, ACE inhibitors, angiotensin II antagonists and beta blockers.
CHICAGO -- Spironolactone and statins added to ACE inhibitors and angiotensin II receptor blockers further reduces proteinuria and the rate of chronic kidney disease progression, a study has found.
Normally, ACE converts the compound angiotensin I into angiotensin II, which induces the blood vessels to constrict and blood pressure to rise.
Louis, MO), a disease management company that uses its expertise in medical genomics to improve clinical outcomes in as many species as possible, announced that it has entered into a multi- year collaborative agreement with Italy's National Institutes of Health, to test GenoMed's patent-pending use of angiotensin II inhibitors to treat avian influenza in poultry.
The market for hypertensives - led by the angiotensin II antagonists - is one of the largest and most profitable in the global pharmaceutical market, with total anti-hypertensive sales of $36600m in 2006.

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