ANGPT2

(redirected from angiopoietin 2)

ANGPT2

A gene on chromosome 8q23.1 that encodes angiopoietin 2, a secreted glycoprotein which, like other angiopoietins, binds to endothelial cell-specific tyrosine-protein kinase receptor. Angiopoietin 2 is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2/TEK); it disrupts ANGPT1’s vascular remodelling activity and may induce endothelial cell apoptosis.
Mentioned in ?
References in periodicals archive ?
compensatory proangiogenic (10) factors by host cells, for instance VEGF, PlGF, G-CSF, osteopontin, angiopoietin 2, PDGFA, and SDF1[alpha] BMDC mobilization of myeloid Shojaei et al.
First-in-human dose-escalation safety and PK trial of a novel intravenous humanized monoclonal CovX body inhibiting angiopoietin 2.
20) Angiopoietin 2 (Ang2) and vascular EGF (VEGF) inductions correlate remarkably well with this process.
Phase 1b safety trial of CVX-060, an intravenous humanized monoclonal CovX body inhibiting angiopoietin 2 (ang-2), with sunitinib (Poster discussion, Abstract #3032, June 2)
First-in-human dose-escalation safety and PD trial of a novel humanized monoclonal CovX body inhibitor of angiopoietin 2 and vascular endothelial growth factor.
the regulatory factors; vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF), angiopoietin 1, angiopoietin 2, etc.
Findings Published in Nature Medicine Show Potential for RNAi Therapeutic Targeting Angiopoietin 2