Clinically and morphologically, cellular angiofibroma can simulate other benign tumours like leiomyoma, angiomyofibroblastoma, spindle cell lipoma and perineurioma (1, 5).
Cellular angiofibroma: a benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma.
Normal vulvar tissue and different lesions of vulva have been surveyed for hormonal milieu receptors such as vulvar cancers, Cavernous lymphangiomas, angiomyofibroblastoma, angiomyxoma, indicating ER and PR importance in disease pathogenesis (16, 17, 18, 19) the positivity rate for ER in normal vulvar tissue varies from 33-100% (20) and it's also positive in most of CA lesions and normal vaginal epithelium (5).
Angiomyofibroblastoma of the vulva during pregnancy.
There was strong nuclear positivity in 90% of AAMs compared with weaker reactivity in 27% of fibroepithelial stromal polyps and no staining in angiomyofibroblastoma or cellular angiofibroma.
Angiomyofibroblastoma is a more recently described, benign, myxoid, and vascular soft tissue neoplasm of the vulva.
1] CAF share pathological features of angiomyofibroblastoma and aggressive angiomyxoma (AAM), but do not fall into either category.
Angiomyofibroblastoma like tumor of the male genital tract; analysis of 11 cases with comparison to female angiomyofibroblastoma and spindle cell lipoma.
Included in this latter group are nodular fasciitis, fibromatoses, angiomyofibroblastoma
, sarcomas with a prominent myofibroblastic component, and malignant fibrous histiocytoma.
1] More recently, since the first description by Fletcher et al, angiomyofibroblastoma (AMFB) of the female vulvovaginal tract has been recognized as an essentially benign angiomyxoid neoplasm histologically distinct from AAM.
Angiomyofibroblastoma of the vulva: a benign neoplasm distinct from aggressive angiomyxoma.
6) Jones and colleagues, who studied a series of 9 cases, proposed further categorizing benign fibromatous testicular and paratesticular lesions into fibromas of testicular tunics or of gonadal stromal origin, angiomyofibroblastomas
and fibroblastic/myofibroblastic pseudotumours.