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angiogenic factor

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angiogenic factor
Any of a group of substances present in the circulation–most of which are polypeptides–eg, angiogenin, fibroblast growth factor, transforming growth factors, some lipids which help form blood vessels; AFs ↑ after myocardial ischemia


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Obesity is characterised by mild inflammation, and WAT may be the main locus of the inflammatory state, producing cytokines, chemokines, acute-phase proteins and angiogenic factors.
The genes involved range from hypoxic and angiogenic factors to those with tumour-associated macrophage functions, and are biologically relevant as they are known to be associated with outcome.
The cellular component is made up of stromal cells (fibroblasts and macrophages), inflammatory cells [macrophages, lymphocytes, natural killer (NK) cells, dendritic cells (DCs)] and endothelial cells, whereas the soluble component contains cytokines, chemokines and stromal, inflammatory and angiogenic factors (both pro- and anti-angiogenic).
 
 
 
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