angiogenesis


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to angiogenesis: Anti-angiogenesis, Angiogenesis inhibitors

angiogenesis

 [an″je-o-jen´ĕ-sis]
1. development of blood vessels in the embryo.
2. any formation of new blood vessels; see also neovascularization (def. 2) and revascularization. Called also angiopoiesis and vasculogenesis. adj., adj angiogenic.
tumor angiogenesis the induction of the growth of blood vessels from surrounding tissue into a tumor by a diffusible protein factor released by the tumor cells.

an·gi·o·gen·e·sis

(an'jē-ō-jen'ĕ-sis),
Development of new blood vessels.
Synonym(s): arteriogenesis
[angio- + G. genesis, production]

angiogenesis

/an·gio·gen·e·sis/ (-jen´ĕ-sis) vasculogenesis; development of blood vessels either in the embryo or in the form of neovascularization or revascularization.

angiogenesis

(ăn′jē-ō-jĕn′ĭ-sĭs)
n. pl. angiogene·ses (-sēz′)
The formation of new blood vessels.

an′gi·o·gen′ic (-jĕn′ĭk) adj.

angiogenesis

[an′jē·ōjen′əsis]
Etymology: Gk, angeion + genesis, origin
the formation of new blood vessels, a process controlled by chemicals produced in the body that stimulate blood vessels or form new ones. Angiogenesis plays an important role in the growth and spread of cancer. Angiogenesis also occurs in the healthy body for healing of wounds and restoring blood flow to tissues after injury.

angiogenesis

The development of new blood vessels from pre-existing vessels. Angiogenesis plays a fundamental role in embryonic development, tissue and wound repair, resolution of inflammation, and onset of neoplasia. It is linked to an array of pathological conditions (e.g., cancer, diabetic retinopathy, rheumatoid arthritis).

angiogenesis

The sprouting of new blood vessels and capillary beds from existing vessels, which plays a fundamental role in embryonic development, tissue and wound repair, resolution of inflammation, and onset of neoplasia; angiogenesis is linked to certain pathologies–eg, cancer, diabetic retinopathy, rheumatoid arthritis

an·gi·o·gen·e·sis

(an'jē-ō-jen'ĕ-sis)
1. Development of blood vessels in the embryo. 2. Any formation of new blood vessels.
[angio- + G. genesis, production]

angiogenesis

The origination and development of new capillary blood vessels in normal or malignant tissue. Angiogenesis is necessary so that a growing or enlarging tissue, with its increasing metabolic needs, obtains an adequate blood supply providing oxygen, nutrients and waste drainage. Various angiogenetic factors are secreted by blood-deprived (ischaemic) cells and these operate on the inner lining (endothelium) of existing blood vessels to cause the budding out of new capillaries. Angiogenesis can be exploited in two ways in medicine-it can, in theory be inhibited in the treatment of CANCER, DIABETIC RETINOPATHY, obesity, ENDOMETRIOSIS and ATHEROSCLEROSIS; or it can be encouraged to treat heart attacks, ununited fractures, neurodegenerative disease, peripheral blood circulation deficiencies and baldness.

angiogenesis

process of forming new blood vessels, normally accompanies the growth of MALIGNANT tissue. TUMOURS need angiogenesis to provide the nutrients and oxygen for development and METASTATIS.

Angiogenesis

The formation of new blood vessels, for example, as a result of a tumor.

angiogenesis (anˈ·jē·ō·jeˑ·n·sis),

n the formation and growth of new blood vessels.

VEGF (vascular endothelial growth factor) 

A major protein involved in regulating the differentiation and proliferation of vascular endothelial cells thus promoting the growth of new blood vessels (angiogenesis). VEGF is essential for normal embryonic development and contributes to the maintenance and repair of tissues. There are several VEGF proteins, depending on the number of amino acids that they contain (e.g. VEGF 121, VEGF 165, VEGF 189 and VEGF 206). However, under certain circumstances (e.g. higher than normal levels of VEGF as happens in hypoxia) it may participate in cancerous processes, inflammatory processes (e.g. rheumatoid arthritis) and ocular neovascularization as in exudative (wet) age-related macular degeneration and diabetic retinopathy. Anti-VEGF drugs are used to inhibit the action of VEGF. See anti-VEGF drugs.

angiogenesis

the development of blood vessels.

tumor angiogenesis
the induction of the growth of blood vessels from surrounding tissue into a solid tumor by a diffusible chemical factor released by the tumor cells.
References in periodicals archive ?
Integrin Involvement in Angiogenesis (Akalu, Contois, Brooks)
Table 28: Rest of World Historic Review for Angiogenesis
6 Proceedings of the National Academy of Science, she, Folkman, and their colleagues report that some of the same angiogenesis inhibitors now being tested on cancer patients prevent excess weight gain in several different strains of obesity-prone mice.
In adults, angiogenesis occurs naturally, but with limitations.
Table 1: Global Market for Angiogenesis Regulating Products
7 Protein Expression Levels of Identified Targets of Angiogenesis Affecting Cancer Drugs 312
How the drug inhibits angiogenesis remains unclear.
Kerbel of the Toronto-Sunnybrook Regional Cancer Centre notes that researchers are finding evidence that many conventional antitumor drugs may work in part by inhibiting angiogenesis.
The Angiogenesis Foundation is re-conceptualizing a global approach to health by helping the body maintain its normal balance of angiogenesis, the process used by the body to grow new blood vessels.
22, 2014 /PRNewswire/ -- The Angiogenesis Foundation, in collaboration with musician/activist Peter Gabriel, has launched the Do iT Yourself Health Revolution [sup.
Also covered are the effects of obesity, the role of inflammation in stimulating angiogenesis, and possible racial differences in angiogenesis in breast cancer.
The control of angiogenesis is of utmost importance for tissue regenerative therapies as well as cancer treatment, however this remains a challenge.