1) It is rare and also known by follicular lymphoreticuloma, angiofollicular
lymph node hyperplasia, giant cell lymph node hyperplasia, benign giant lymphoma and lymphoid hamartoma.
lymph node hyperplasia in children: a clinicopathologic study of eight patients.
Multicentric angiofollicular lymph node hyperplasia (Castleman's disease) followed by Kaposi's sarcoma in two homosexual males with the acquired immunodeficiency syndrome (AIDS).
Kaposi's sarcoma in a young homosexual man: association with angiofollicular lymphoid hyperplasia and a malignant lymphoproliferative disorder.
Also called angiofollicular
or giant lymph node hyperplasia, multicentric Castleman's disease is an atypical lympho-proliferative disorder characterized by the growth of tumors in lymph node tissue.
Castleman disease, also known as angiofollicular
lymph node hyperplasia, occurs in 2 forms.
Vascular endothelial growth factor is also being investigated as a contributor to the pathogenesis of hyperplastic angiofollicular
lymphoid lesions,s In addition, a chromosomal abnormality (46,XX,t(1; 16)(p11;p11),del(7)(q21q22),del(8)(q12q22)) has recently been demonstrated in dysplastic stromal cells from a case of the hyaline-vascular type, suggesting that these tumors may be in part clonal and questioning the current concept that this disease entity is best classified as a hyperplastic process.
Small vessel proliferation and hyalinization in the interfollicular areas and within angiofollicular
structures in adjacent portal areas may be a prominent finding, which may mimic the hyaline-vascular type of Castleman disease.