intravascular large B-cell lymphoma

(redirected from angioendotheliomatosis proliferans)

intravascular large B-cell lymphoma

A high-grade non-Hodgkin lymphoma arising in and generally confined to vascular lumina, which usually begins in the skin and CNS and rapidly spreads elsewhere.

Clinical findings
Often begins with fever of unknown origin and nonspecific cutaneous (e.g., plaques) and neurologic complaints.
 
DiffDx
Skin lesions (erythematous/purple plaques on the trunk and lower legs) may be confused with mycosis fungoides, sarcoidosis, vascular neoplasms (e.g., Kaposi sarcoma) or involvement by lymphoma or leukaemia.

Prognosis
Extremely poor; short survival is the norm despite aggressive chemotherapy. The diagnosis is often established postmortem.
References in classic literature ?
As confidence was out of the question with The Avenger in the hall, which could merely be regarded in the light of an ante-chamber to the keyhole, I sent him to the Play.
The ante-chamber was full of police agents and gendarmes, in the midst of whom, carefully watched, but calm and smiling, stood the prisoner.
Collins pointed out, with a rapturous air, the fine proportion and the finished ornaments, they followed the servants through an ante-chamber, to the room where Lady Catherine, her daughter, and Mrs.
Any one who happened at that moment to contemplate that red simar -- the gorgeous robe of office -- and the rich lace, or who gazed on that pale brow, bent in anxious meditation, might, in the solitude of that apartment, combined with the silence of the ante-chambers and the measured paces of the guards upon the landing-place, have fancied that the shade of Cardinal Richelieu lingered still in his accustomed haunt.
The sou was given, and the porter's daughter disappeared, leaving Adrienne alone in the ante-chamber.
The soldier made a profound bow, and, as if the name of the conqueror of Rocroy and Sens had given him wings, he stepped lightly up the steps leading to the ante-chamber.
Oh, just let some peas be strewn in the ante-chamber,' answered the lion, 'and then you will soon see.
It opened into a small chamber, luxuriously furnished, and was evidently an ante-chamber off some office or audience chamber of the palace.
At last, however, on the repeated positive assurance that he really was Prince Muishkin, and must absolutely see the general on business, the bewildered domestic showed him into a little ante-chamber leading to a waiting-room that adjoined the general's study, there handing him over to another servant, whose duty it was to be in this ante-chamber all the morning, and announce visitors to the general.
But, as we have said, in the first ante-chamber he had stopped, solely for the sake of not mixing himself with all those happy beings he felt were moving around him in the adjacent salons.
He hath here a parlour and ante-chamber to himself, where he gets drunk with whom he pleases: and his daughter is still as ready as formerly to play to him whenever he desires it; for Jones hath assured her that, as, next to pleasing her, one of his highest satisfactions is to contribute to the happiness of the old man; so, the great duty which she expresses and performs to her father, renders her almost equally dear to him with the love which she bestows on himself.
It was indeed time for that, for as I was about to place my legs through the window, the man had seen me, had bounded to his feet, had sprung--as I foresaw he would--to the door of the ante-chamber, had time to open it, and fled.