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anergy

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anergy /an·er·gy/ (an´er-je)
1. extreme lack of energy.
2. diminished reactivity to one or more specific antigens.aner´gic

an·er·gy (nr-j)
n.
Absence of sensitivity to substances that would normally elicit an antigenic response.

an·ergic (-nûrjk, nr-) adj.

anergy
[an′ərjē]
Etymology: Gk, a, ergon, not work
1 lack of activity, lack of energy leading to inactivity.
2 an immunodeficient condition characterized by a lack of or diminished reaction to an antigen or group of antigens. This state may be seen in advanced tuberculosis and other serious infections, acquired immunodeficiency syndrome, and some malignancies. anergic, adj.

anergy (an´urjē),
n in terms of hypersensitivity, an inability to react to specific antigens (i.e., lack of reaction to intradermally injected antigens in measles, Hodgkin's sarcoma, and overwhelming tuberculosis).

anergy
diminished reactivity to specific antigen(s).

anergy
Immunology Depression or absence of an immune response to an antigen to which the host was previously sensitive; it is characterized by ↓/absent lymphokine secretion by viable T cells when the T cell receptor is engaged by an antigen; it can be tested by loss of delayed hypersensitivity–eg, to PPD, Candida antigens, or DCNB. See Clonal anergy, Deletion. Cf Allergy.


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Skin test anergy among injection drug users recruited from community settings.
A controlled trial of isoniazid in persons with anergy and human immunodeficiency virus infection who are at high risk for tuberculosis.
"If oral tolerance works only through T-cell anergy, we might have to find the right part of myelin to feed each person with MS," Weiner said.
 
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